Dr. J. Briggs

Dr. J. Briggs 2018-01-17T21:03:39+00:00

Dr. John Briggs

Medical Research Council Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge CB2 0QH
United Kingdom
Tel: +44 1223 267245
Email: jbriggs@mrc-lmb.cam.ac.uk

The European Molecular Biology Laboratory (EMBL) Heidelberg
69117 Heidelberg, Germany
Phone: +49 6221-387-8482
Fax:      +49 6221-387-8519
Email:   briggs@embl.de

FIELDS OF INTEREST

Enveloped virus structure, assembly and budding, cellular vesicle budding mechanisms, cryo-electron tomography methods, correlative light and electron microscopy methods.

CURRENTLY FUNDED PROJECTS

DFG BR 3635/2-1 “Die Struktur des assemblierten, unreifen Gag-Proteinnetzwerks von Retroviren”
ERC Consolidator grant ERC-2014-CoG 648432. “Structure and mechanism of viral and cellular membrane fusion machineries”
EU project 653706 – iNEXT. “Infrastructure for NMR, EM and X-ray crystallography for translational research”

AWARDS & HONORS

2012 Chica and Heinz Schaller Research Award
2014 Yale University Sears Lecture
2015 Royal Microscopical Society Medal for Life Sciences
2015 Elected to EMBO Membership
2015 Ernst-Ruska prize for outstanding achievements in electron microscopy
2018 Blavatnik Awards UK Finalist

2017-present Programme Leader, Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K.
2017-present Group Leader and Senior Scientist (part-time), European Molecular Biology Laboratory, Heidelberg, Germany
2013-2016 Senior Scientist, European Molecular Biology Laboratory
2006 Group Leader – Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
2005-2006 Postdoctoral Research Fellow, Ludwig Maximilians University Munich, Germany
2004 Postdoctoral Scientist, Oxford University, U.K.
2000 – 2004 D.Phil. in Structural Biology, Oxford University, U.K
1996 – 2000 Bachelor (B.A.) and Master (M.Sci.) in Natural Sciences (Biochemistry) Cambridge University

2017 – present Institut de Biologie Structurale Grenoble scientific advisory board member
2016 – present FEBS Letters editorial board member
2015 – present Max-Planck Institute of Molecular Cell Biology and Genetics scientific advisory board member
2013 France-BioImaging scientific advisory board member
2009 – present Electron Microscopy Core Facility Committee Member
2008 – present Graduate Program Committee Member
2008 – 2011 Science & Society Committee Member

Bykov YS, Schaffer M, Dodonova SO, Albert S, Plitzko JM, Baumeister W, Engel BD, Briggs JA (2017). The structure of the COPI coat determined within the cell. eLife 2017 :6. pii: e32493. doi: 10.7554/eLife.32493

Adell MAY, Migliano, SM, Upadhyayula, S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JAG, Kirchhausen T, Teis D (2017). Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. eLife, 6:e31652

Wan W, Kolesnikova L, Clarke M, Koehler A, Noda T, Becker S, Briggs JAG (2017). Structure and assembly of the Ebola virus nucleocapsid. Nature 551, 394-397

Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov Y, Sonnen, AF-P, Lihl R, Briggs JAG (2017). New hardware and workflows for semi-automated correlative cryo-fluoresence and cryo-electron microscopy/tomography. Journal of Structural Biology 197, 83-93

Schur FKM, Obr M, Hagen WJH, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich HG, Briggs JAG (2016).  An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Science 353, 506-508

Mattei S, Glass B, Hagen WJH, Kräusslich HG, Briggs JAG (2016).  The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 354, 1434-1437

Bykov YS, Cortese M, Briggs JAG, Bartenschlager R (2016). Correlative light and electron microscopy methods for the study of virus-cell interactions (review). FEBS letters 590, 1877-1895

Chlanda P, Schraidt O, Kummer S, Riches J, Oberwinkler H, Prinz S, Kräusslich HG, Briggs JAG (2015).  Structural analysis of the roles of influenza A virus membrane-associated proteins in assembly and morphology.  Journal of Virology 89, 8957-8966

Kukulski W, Schorb M, Kaksonen M, Briggs JAG (2012). Plasma membrane reshaping during endocytosis revealed by time-resolved electron tomography. Cell 150, 508-520

Bharat TAM, Davey NE, Ulbrich P, Riches JD, de Marco A, Rumlova M, Sachse C, Ruml T, Briggs JAG (2012). Structure of the immature retroviral capsid at 8Å resolution by cryo-electron microscopy. Nature 487, 385-9

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