Dr. John Briggs

The European Molecular Biology Laboratory (EMBL) Heidelberg
69117 Heidelberg, Germany

Phone: +49 6221-387-8482
Fax:      +49 6221-387-8519
Email:   briggs@embl.de

FIELDS OF INTEREST

Enveloped virus structure, assembly and budding, cellular vesicle budding mechanisms, cryo-electron tomography methods, correlative light and electron microscopy methods.

CURRENTLY FUNDED PROJECTS

SFB638 project A16 “Structural Dynamics of Coatomer”
DFG BR 3635/2-1 “Die Struktur des assemblierten, unreifen Gag-Proteinnetzwerks von Retroviren”

2006 – present Group Leader at EMBL Structural & Computational Biology Unit
2005-2006 Postdoctoral research fellow at Ludwig Maximilians University Munich, Germany
2004 Postdoctoral research Oxford University
2000 – 2004 D.Phil. in Structural Biology, Oxford University, U.K
1996 – 2000 Bachelor (B.A.) and Master (M.Sci.) in Natural Sciences (Biochemistry) Cambridge University

2009 – present Electron Microscopy Core Facility Committee Member
2008 – present Graduate Program Committee Member
2008 – 2011 Science & Society Committee Member

Kukulski W, Schorb M, Kaksonen M, Briggs JAG. Plasma membrane reshaping during endocytosis revealed by time-resolved electron tomography. Cell, 2012; 150, 508-520

Bharat TAM, Davey NE, Ulbrich P, Riches JD, de Marco A, Rumlova M, Sachse C, Ruml T, Briggs JAG. Structure of the immature retroviral capsid at 8Å resolution by cryo-electron microscopy. Nature, 2012; 487, 385-9

Faini M, Prinz S, Beck R, Schorb M, Riches JD, Bacia K, Brügger B, Wieland FT, Briggs JAG. The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions. Science, 2012; 336, 1451-4

Bharat TA, Riches JD, Kolesnikova L, Welsch S, Krahling V, Davey N, Parsy ML, Becker S, Briggs JAG. Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells. PLoS Biology 2011; 9: e1001196

Briggs JAG, Riches JD, Glass B, Bartonova V, Zanetti G and Kräusslich HG, Structure and assembly of immature HIV. Proceedings of the National Academy of Sciences 2009; 106, 11090-11095

Click here for further publications.