Dr. John Briggs

The European Molecular Biology Laboratory (EMBL) Heidelberg
69117 Heidelberg, Germany

Phone: +49 6221-387-8482
Fax:      +49 6221-387-8519
Email:   briggs@embl.de

FIELDS OF INTEREST

Enveloped virus structure, assembly and budding, cellular vesicle budding mechanisms, cryo-electron tomography methods, correlative light and electron microscopy methods.

CURRENTLY FUNDED PROJECTS

SFB638 project A16 “Structural Dynamics of Coatomer”
DFG BR 3635/2-1 “Die Struktur des assemblierten, unreifen Gag-Proteinnetzwerks von Retroviren”

2006 – present Group Leader at EMBL Structural & Computational Biology Unit
2005-2006 Postdoctoral research fellow at Ludwig Maximilians University Munich, Germany
2004 Postdoctoral research Oxford University
2000 – 2004 D.Phil. in Structural Biology, Oxford University, U.K
1996 – 2000 Bachelor (B.A.) and Master (M.Sci.) in Natural Sciences (Biochemistry) Cambridge University

2009 – present Electron Microscopy Core Facility Committee Member
2008 – present Graduate Program Committee Member
2008 – 2011 Science & Society Committee Member

Kukulski W, Schorb M, Kaksonen M and Briggs JAG, Plasma membrane reshaping during endocytosis revealed by time-resolved electron tomography. Cell, 2012; 150, 508-520

Bharat TAM, Davey NE, Ulbrich P, Riches JD, de Marco A, Rumlova M, Sachse C, Ruml T and Briggs JAG, Structure of the immature retroviral capsid at 8Å resolution by cryo-electron microscopy. Nature, 2012; 487, 385-9

Faini M, Prinz S, Beck R, Schorb M, Riches JD, Bacia K, Brügger B, Wieland FT and Briggs JAG, The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions. Science, 2012; 336, 1451-4

Bharat TA, Riches JD, Kolesnikova L, Welsch S, Krahling V, Davey N, Parsy ML, Becker S and Briggs JAG, Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells. PLoS Biology 2011; 9: e1001196

Briggs JAG, Riches JD, Glass B, Bartonova V, Zanetti G and Kräusslich HG, Structure and assembly of immature HIV. Proceedings of the National Academy of Sciences 2009; 106, 11090-11095

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