Dr. Steeve Boulant

Department of Infectious Diseases, Virology
University Hospital Heidelberg
69120 Heidelberg, Germany

Phone: +49 6221-42 1560
Email:   s.boulant@dkfz-heidelberg.de

FIELDS OF INTEREST

Virus entry, virus-host interactions, anti-viral innate immune eresponse in intestinal polarized epithelium cells, viral commensal intestinal flora, molecular mechanisms triggering viral particle entry, characterization of the dynamic uptake and intracellular trafficking of viral pathogen using live-cell confocal microscopy, quantification of virus-receptor interaction using TORF microscope and characterization of the impact of receptor clustering on virus entry, intracellular locatioan and functional aspects of innate immunity sensor proteins (TLR and RLR) in polarized cells.

CURRENTLY FUNDED PROJECTS

Chica and Heinz Schaller Fundation grant (2012-2017). Currently supervising 1 doctoral thesis, 2 post-doctoral fellows and 1 technician.

AWARDS & HONORS

2011 Post-doctoral fellowship (2011-2012), GlaxoSmithKline, Boston MA, USA
2010 Pilot and Feasiblity award program HDDC, Boston MA, USA
2009 Pilot and Feasiblity award program HDDC, Boston MA, USA
2007 Poster award, FASEB Liqid Droplets conference, Vermont USA
2006 Post-doctoral fellowship Marie-Curie IEF (2006-2008), Glasgow, UK
2006 Best Oral communication, UK Meeting on the Biology and Pathology of HCV
2005 Post-doctoral fellowship (2005-2006), MRC, Glasgow, UK
2005 Travel award, 11th Interantional Meeting on HCV and Related Viruses
2004 Bridging grant, FRM (2004-2005), Lyon, France
2001 EURODOC fellowsgip, Lyon-Glasgow exchange grant

2012-present Junior Group Leader CHS Foundation, University Hospital Heidelberg
2008-2012 Post doctoral associate, Harvard Medical School Boston MA, USA
2006-2008 Marie curie Post doctoral fellow, MRC Virology Unit Glasgow, UK
2005-2006 Post doctoral associate, MRC Virology Unit Glasgow, UK
2004-2005 Bridging grant fellow, IBCP-CNRS Lyon, France
2001-2004 PhD in Molecular Biology and Biochemistry, IBCP-CNRS, France
2000-2001 DEA in Molecular Biology and Biochemistry (Master), Lyon, France
1998-2000 Bachelor degree in Molecular Biology and Biochemistry, Lyon, France
1996-1998 Classe préparatoire Mathematic superior, Lycée Ozenne, Toulouse, France

2010 Co-organisor of live-cell imaging workshop, Harvard Medical School, USA

Blaising J, Lévy PL, Gondeau C, Phelip C, Varbanov M, Teissier E, Ruggiero F, Polyak SJ, Oberlies NH, Ivanovic T, Boulant S*, Pécheur EI* 2013. Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking. Cell Microbiol. 2013 May 24.

Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T 2013. Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. Apr;24(8):1196-207.

The first five seconds in the life of a clathrin coated pit
Ema Cocucci, Francois Aguet, Steeve Boulant and Tom Kirchhausen, Cell, 2012 Aug 3; 150(3):495-507

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.
Steeve Boulant#, Comert Kural#, Jean-Christophe Zeeh and Tom Kirchhausen, Nat Cell Biol 2011 Aug 14;13(9):1124-31

Peroxisomes and mitochondria cooperate to induce antiviral innate immunity
Evelyn Dixit, Steeve Boulant, Yijing Zhang, Amy S. Lee, Bennett O.V. Shum, Nir Hacohen, Zhijian J. Chen, Sean P. Whelan, Marc Fransen, Max L. Nibert, Giulio Superti-Furga, Jonathan C. Kagan, Cell, 2010 May 14;141(4):668-81

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