apl. Prof. Dr. Barbara Müller

Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 1325
Fax:      +49 6221-56 5003


Biology of human immunodeficiency virus. Focus of current work: live-cell imaging of HIV-1 cell interactions; analysis of dynamics of HIV cell entry and HIV particle formation; HIV assembly and maturation; quantitative analysis of HIV replication steps


Project 6 in SFB1129 (1 Postdoc); DFG Grant MU885/5-1 (2 PhD students); EcTop programme of the CellNetworks Cluster of Excellence, EXC81 (1 Masters Student)


1992-1997 Postdoctoral Fellowship (AIDS-Stipendienprogramm BMBF)

2000–present Group leader at the Department of Infectious Diseases, Virology, Heidelberg University
2015 apl. Prof. at the Heidelberg University
2004 Habilitation in Experimental Virology (Heidelberg University)
1995–2000 Postdoctoral fellow/ research associate, Heinrich-Pette-Institute, Hamburg, Department of Cell Biology and Virology
1995 Postdoctoral fellow , German Cancer Research Center Heidelberg
Postdoctoral fellow, Fox Chase Cancer Center Philadelphia PA, USA
Postdoctoral associate, Max-Planck-Institute for Medical Research Heidelberg
1991 PhD (Dr. rer. nat.), University of Heidelberg
1988–1991 PhD thesis (Max-Planck-Institute for Medical Research Heidelberg, lab of Prof. R.S.Goody)
1987 Diploma (University of Heidelberg)
1981–1986 Study of Biology, Technical University Darmstadt and University of Heidelberg

SELECTED PUBLICATIONS  (**:corresponding author)

Sakin V, Hanne J, Dunder J, Anders-Össwein M, Laketa V, Nikić I, Kräusslich HG, Lemke EA, Müller B (2017). A versatile tool for live-cell imaging and super-resolution nanoscopy studies of HIV-1 Env distribution and mobility. Cell Chem Biol. 24:635-645.e5

Sakin V, Paci G, Lemke EA, Müller B (2016). Labeling of virus components for advanced, quantitative imaging analyses. FEBS Lett. 590:1896-1914

Schimer J, Pavova M, Anders M, Pachl P, Sacha P, Cigler P, Weber J, Majer P, Rezacova P, Kräusslich HG, Müller B*, Konvalinka J* (2015). Triggering HIV polyprotein processing inside virions by rapid photodegradation of a tight-binding photodestructable protease Inhibitor. Nature Communications. 6:6461

Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC (2015). Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers. J Cell Biol. 210(4):629-646

Schur FKM, Hagen WJH, Rumlova M, Ruml T, Müller B, Kräusslich HG, Briggs JAG (2015). Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution, Nature 517:505-508

Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG (2014). Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. Elife 3:e04114

Mattei S, Anders M, Konvalinka J, Kräusslich HG, Briggs JAG, Müller B (2014). Induced maturation of human immunodeficiency virus. J Virol. 88:13722-13731

Chojnacki J, Staudt T, Glass B, Bingen P, Engelhardt J, Anders M, Schneider J, Müller B, Hell SW, Kräusslich HG (2012). Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. Science 338:524-528

Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich HG, Bräuchle C, Müller B**, Lamb DC** (2011). Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component. Nat Cell Biol 13:469-474

Ivanchenko S, Godinez WJ, Lampe M, Kräusslich HG, Eils R, Rohr K, Bräuchle C, Müller B**, Lamb DC** (2009). Dynamics of HIV-1 assembly and release. PLoS Pathog 5:e1000652

Click here for a complete list of scientific publications.