Priv.-Doz. Dr. Jacomine Krijnse-Locker   

Electron microscopy core facility and Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-54 51412
Fax:      +49 6221-56 51824
Email:   jacomine.krijnse@bioquant.uni-heidelberg.de

Jacomine Krijnse-Locker has led Project Z2 together with John Briggs from October 2014-April 2015. Since May 2015 her group is located at the Institut Pasteur, Paris.

FIELDS OF INTEREST

Virology, assembly of large DNA viruses, cell biology, dynamics of membranes, cell biology of viruses, electron microscopy, imaging of viral and cellular membranes, 3D microscopy

CURRENTLY FUNDED PROJECTS

DFG-Einzelantrag 2013-2016: KR 2173/3-1 ‘membrane rupture as an alternative membrane assembly pathway’

AWARDS & HONORS

1990-1994 PhD fellowship ‘Dutch organization for scientific research’ (NWO)
1994-1996 Post-doctoral fellowship from ‘Human science frontiers program organization’

2009-present co-head of the EM core facility of Heidelberg University
2007-present Group leader at the Department of Infectious Diseases, Virology &Molecular Virology, Heidelberg University
1997-2006 Scientist, EMBL, Heidelberg
2003 Habilitation, Heidelberg University (cell biology)
1994-1997 post-doctoral fellow EMBL, Heidelberg, cell biology program
1990-1994 PhD in virology and cell biology, University of Utrecht, Utrecht, theNetherlands

2001 Main organizer of EMBO-workshops ‘Cell Biology of Virus Infections’, EMBL, Heidelberg, September 2001
2004-2007 co-head (together with Dr. Stephan Urban) of the study section cellbiology of the German society for Virology
2004 Main organizer second EMBO workshop “Cell Biology of Virus Infections’. EMBL, Heidelberg, September 2004

Shah PNM, Stanifer ML, Hohn K, Engel U, Haselmann U, Bartenschlager R, Kräusslich HG, Krijnse-Locker J, Boulant S (2017). Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network. Cellular Microbiology doi: 10.1111/cmi.12765. [Epub ahead of print]

Chlanda P, Krijnse Locker J (2017). The sleeping beauty kissed awake; new methods in electron microscopy to study cellular membranes. Biochemical J.  474(6):1041-1053

Chlanda P, Carbajal MA, Cyrklaff M, Griffiths G, Krijnse Locker J (2009). Membrane rupture generates single open membrane sheets during vaccinia virus assembly. Cell Host & Microbe 6, 81-90

Pan X, Rudolph JM, Abraham L, Habermann A, Haller C, Krijnse-Locker J, Fackler OT (2012). HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling. Blood 119, 786-797.

Romero-Brey I, Merz A, Chiramel A, Lee JY, Chlanda P, Haselman U, Santarella-Mellwig R, Habermann A, Hoppe S, Kallis S, Walther P, Krijnse Locker J, Bartenschlager R (2012). Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog 8, e1003056.

Suárez C, Welsch S, Chlanda P, Hagen W, Hoppe S, Kolovou A, Pagnier I, Raoult D, Krijnse Locker J (2013). Open membrane-intermediates are the precursors for assembly of large DNA viruses. Cell Microbiol. 15(11) :1883-95. doi: 10.1111/cmi.12156. Epub 2013 Jul 5.

Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CKE, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R (2009). Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host & Microbe 5, 365-375

Welsch S, Keppler OT, Habermann A, Allespach I, Krijnse Locker J, Kräusslich HG (2007). The primary site of HIV-1 budding in infected primary macrophages is the plasma membrane. PLOS Pathog 3, 1-11

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