Brügger, Britta

Prof. Dr. Britta Brügger

Heidelberg University Biochemistry Center (BZH)
69120 Heidelberg, Germany

Phone: +49 6221-54 5326
Fax:      +49 6221-54 4366


Protein-lipid interactions, roles of lipids in fusion and fission of viral particles, regulation of membrane receptor activity by lipids, lipids as cofactors for protein function, intracellular lipid sorting, lipidomics, electrospray-ionisation high resolution mass spectrometry.


SFB 638 A10, SFB/TRR 83 TP1, BMBF IntenC Programm. Currently supervising 6 doctoral theses.


2015 Walter A. Shaw Young Investigator Award in Lipid Research
2000 – 2002 Peter and Traudl Engelhorn fellowship
1998 – 2000 EMBO long term fellowship
1998 PhD with summa cum laude

since 2014 W3 professor at the Heidelberg University Biochemistry Center
2007 Habilitation, University of Heidelberg
2006-present Head of CellNetworks Lipidomis platform, Heidelberg
2002-present Senior Scientist, Heidelberg University Biochemistry Center
2000-2002 Postdoctoral research fellow at the Heidelberg University Biochemistry Center, Heidelberg
1998-2000 Postdoctoral research fellow at the Memorial Sloan Kettering Cancer Center, New York, USA
1994-1998 PhD thesis with Prof. Dr. Felix Wieland at Institute for Biochemistry, Ruprecht Karls University, Heidelberg
1993-1994 Diploma thesis at Göttingen University
1990-1993 Studies in Biochemistry at Frankfurt University
1988-1990  Studies in Biology at Frankfurt University

2010-2013 Vice-coordinator SFB/TRR 83

Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, and Brügger B. Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain. Nature 2012 Jan 9;481(7382): 525-9

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008 Feb 29;319(5867):1244-7

Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B. Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 2008 Jan;49(1):251-62

Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG. The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A. 2006 Feb 21;103 (8):2641-6

Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT. Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 2000 Oct 30;151(3):507-18

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