Prof. Dr. Hans-Georg Kräusslich
Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany
Phone: +49 6221-56 5001
Fax: +49 6221-56 5003
Email: hans-georg.kraeusslich@med.uni-heidelberg.de
FIELDS OF INTEREST
Molecular virology; cell biology of virus infection; assembly, release and molecular architecture of HIV particles; HIV Protease and antiviral resistance; HIV-cell interactions; Role of lipids in HIV replication; Transmission and therapy of HIV infection.
CURRENTLY FUNDED PROJECTS
SFB638, project A9; TRR83, project 14; GRK1188; DFG project BR3635/2-1; BMBF Nanocombine; BMBF ebio Immunoquant; DZIF TTU HIV.
AWARDS & HONORS
| 2017 | Elected Member American Academy of Microbiology |
| 2009 | Heinz Ansmann Award for AIDS research |
| 2008 | Member Heidelberg Academy of Sciences |
| 2008 | HMLS Research Award, Heidelberg |
| 2007 | Faculty medal of Heidelberg University Medical Faculty |
| 2006 | Member of the Deutsche Akademie der Naturforscher Leopoldina |
| 2004–present | Director Department of Infectious Diseases, Heidelberg University |
| 2000–present | Full professor and head of virology, Heidelberg University |
| 1995–1999 | Full professor and head of department, Heinrich-Pette-Institute, Hamburg |
| 1996–1999 | Director, Heinrich-Pette-Institute, Hamburg |
| 1993–1995 | Head of junior department, German Cancer Research Centre, Heidelberg |
| 1990 | Habilitation, University of Heidelberg |
| 1989–1993 | Group leader, German Cancer Research Centre, Heidelberg |
| 1986–1989 | PostDoc, Dept. of Mol. Biology, State Univ. New York at Stony Brook |
| 1985 | MD in experimental virology (Munich) |
| 1977–1984 | Medical School (Munich) |
| 2015–present | Vice-President Heidelberg Academy of Sciences |
| 2014–present | Vice Dean of Research, Medical Faculty, Heidelberg University |
| 2014–present | Speaker SFB 1129 “Integrative analysis of pathogen replication and spread”, Heidelberg University |
| 2007-present | Member founding directorate “BioQuant” |
| 2007–2013 | Director Marsilius-Kolleg (jointly with W. Schluchter) |
| 2006–present | Coordinator Cluster of Excellence “Cellular Networks” |
| 2004–present | Coordinator research program “Infectious diseases”, Heidelberg University |
| 2004–2015 | Member steering committee SFB 638, University of Heidelberg |
| 2005–2012 | Coordinator DFG priority program SPP 1175 “Membrane envelopment” |
| 2002–2011 | Speaker SFB 544 “Control of tropical infectious diseases”, Heidelberg University |
| 2002–2005 | Coordinator collaborative research project “Resistance of human pathogens” (Landesstiftung Baden-Württemberg) |
| 2001–2004 | Coordinator EU (FP5) collaborative project HIV protease inhibitor resistance |
| 1997–2000 | Member steering committee SFB 545, University of Hamburg |
| 1997–1999 | Deputy speaker, DFG research group “RNA trafficking” |
| 1994–1997 | Speaker collaborative BMBF-funded AIDS-research grant, University of Heidelberg |
Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 354(6318):1434-1437
Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-8222
Schur FKM, Hagen WJH, Rumlova M, Ruml T, Müller B, Kräusslich HG, Briggs JAG (2015). Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution. Nature 517:505-8
Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG (2014). Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. Elife. 3:e04114
Muranyi W, Malkusch S, Müller B, Heilemann M, Kräusslich HG (2013). Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail. PLoS Pathog. 9:e1003198
Chojnacki J, Staudt T, Glass B, Bingen P, Engelhardt J, Anders M, Schneider J, Müller B, Hell SW, Kräusslich HG (2012). Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. Science 338: 524-8
Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, *Kräusslich HG, *Martinez-Picado J (2012). Siglec-1 Is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol. 10:e1001448 (*corr. Authors)
Briggs JA, Riches JD, Glass B, Bartonova V, Zanetti G, Kräusslich HG (2009). Structure and assembly of immature HIV. Proc Natl Acad Sci USA 106:11090-5
Carlson LA, Briggs JA, Glass B, Riches JD, Simon MN, Johnson MC, Müller B, Grünewald K, Kräusslich HG (2008). Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host & Microbe 4:592-9
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland F, Kräusslich HG (2006). The HIV lipidome: A raft with an unusual composition. Proc Natl Acad Sci USA 103: 2641-6
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