Prof. Dr. H.-G. Kräusslich

Prof. Dr. H.-G. Kräusslich 2018-01-14T19:43:35+00:00

Prof. Dr. Hans-Georg Kräusslich

Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 5001
Fax:      +49 6221-56 5003
Email:   hans-georg.kraeusslich@med.uni-heidelberg.de

FIELDS OF INTEREST

Molecular virology; cell biology of virus infection; assembly, release and molecular architecture of HIV particles; HIV Protease and antiviral resistance; HIV-cell interactions; Role of lipids in HIV replication; Transmission and therapy of HIV infection.

CURRENTLY FUNDED PROJECTS

SFB638, project A9; TRR83, project 14; GRK1188; DFG project BR3635/2-1; BMBF Nanocombine; BMBF ebio Immunoquant; DZIF TTU HIV.

AWARDS & HONORS

2017 Elected Member American Academy of Microbiology
2009 Heinz Ansmann Award for AIDS research
2008 Member Heidelberg Academy of Sciences
2008 HMLS Research Award, Heidelberg
2007 Faculty medal of Heidelberg University Medical Faculty
2006 Member of the Deutsche Akademie der Naturforscher Leopoldina

2004–present Director Department of Infectious Diseases, Heidelberg University
2000–present Full professor and head of virology, Heidelberg University
1995–1999 Full professor and head of department, Heinrich-Pette-Institute, Hamburg
1996–1999 Director, Heinrich-Pette-Institute, Hamburg
1993–1995 Head of junior department, German Cancer Research Centre, Heidelberg
1990 Habilitation, University of Heidelberg
1989–1993 Group leader, German Cancer Research Centre, Heidelberg
1986–1989 PostDoc, Dept. of Mol. Biology, State Univ. New York at Stony Brook
1985 MD in experimental virology (Munich)
1977–1984 Medical School (Munich)

2015–present Vice-President Heidelberg Academy of Sciences
2014–present Vice Dean of Research, Medical Faculty, Heidelberg University
2014–present Speaker SFB 1129 “Integrative analysis of pathogen replication and spread”, Heidelberg University
2007-present Member founding directorate “BioQuant”
2007–2013 Director Marsilius-Kolleg (jointly with W. Schluchter)
2006–present Coordinator Cluster of Excellence “Cellular Networks”
2004–present Coordinator research program “Infectious diseases”, Heidelberg University
2004–2015 Member steering committee SFB 638, University of Heidelberg
2005–2012 Coordinator DFG priority program SPP 1175 “Membrane envelopment”
2002–2011 Speaker SFB 544 “Control of tropical infectious diseases”, Heidelberg University
2002–2005 Coordinator collaborative research project “Resistance of human pathogens” (Landesstiftung Baden-Württemberg)
2001–2004 Coordinator EU (FP5) collaborative project HIV protease inhibitor resistance
1997–2000 Member steering committee SFB 545, University of Hamburg
1997–1999 Deputy speaker, DFG research group “RNA trafficking”
1994–1997 Speaker collaborative BMBF-funded AIDS-research grant, University of Heidelberg

Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 354(6318):1434-1437

Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-8222

Schur FKM, Hagen WJH, Rumlova M, Ruml T, Müller B, Kräusslich HG, Briggs JAG (2015). Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution. Nature 517:505-8

Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG (2014). Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. Elife. 3:e04114

Muranyi W, Malkusch S, Müller B, Heilemann M, Kräusslich HG (2013). Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail. PLoS Pathog. 9:e1003198

Chojnacki J, Staudt T, Glass B, Bingen P, Engelhardt J, Anders M, Schneider J, Müller B, Hell SW, Kräusslich HG (2012). Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. Science 338: 524-8

Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, *Kräusslich HG, *Martinez-Picado J (2012). Siglec-1 Is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol. 10:e1001448 (*corr. Authors)

Briggs JA, Riches JD, Glass B, Bartonova V, Zanetti G, Kräusslich HG (2009). Structure and assembly of immature HIV. Proc Natl Acad Sci USA 106:11090-5

Carlson LA, Briggs JA, Glass B, Riches JD, Simon MN, Johnson MC, Müller B, Grünewald K, Kräusslich HG (2008). Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host & Microbe 4:592-9

Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland F, Kräusslich HG (2006). The HIV lipidome: A raft with an unusual composition. Proc Natl Acad Sci USA 103: 2641-6

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