Prof. Dr. Michael Lanzer

Department of Infectious Diseases, Parasitology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 7845
Fax:      +49 6221-56 4643
Email:   michael.lanzer@med.uni-heidelberg.de

FIELDS OF INTEREST

Molecular parasitology, host parasite coevolution, drug resistance mechanisms of the malarial parasite; protein trafficking in P. falciparum.

CURRENTLY FUNDED PROJECTS

EU-funded Network of Excellence EVIMalaR; EU-funded PhD Programme EVIMalaR, EU-funded Infrastructure Project INFRAVEC; project within the German Center for Infection Research

AWARDS & HONORS

2011 Heidelberg Molecular Life Science Award
1995 Prize for Tropical Medicine, German Society for Tropical Medicine

2000 Offer of a Professorship at the Seattle Biomedical Institute, USA (declined)
1999-present Full Professor and head of Parasitology, Heidelberg University
1996 Habilitation in Microbiology, University of Würzburg
1994-1998 Junior group leader, Research Center for Infectious Diseases, University of Würzburg
1988-1993 PostDoc, Laboratory of Biochemical Genetics, Sloan-Kettering Institute, New York, USA
1988 PhD Biology Heidelberg University
1979-1984 Biology School (Heidelberg University)

2014-present Member, ERC (European Research Council) panel “Infection & Immunity” (Starting & Consolidator Grants)
2014-present Member, external scientific advisory board of the European Vaccine Initiative (EVI)
2013-present Member, Wellcome Trust PhD Committee
2013-present Member, external scientific advisory board of the ANR-funded French Alliance for Parasitology and Health Care “ParaFrap”
2012-2014 Member, Council for Graduate Studies, Graduate Academy, Heidelberg University
2010-2015 Director, international EVIMalaR PhD Programme
2008-present Director, European Malaria Graduate School
2008-present Member, executive committee, European Network of Excellence “EVIMalaR”
2007-2015 Director (until June 2015), ever since regular EB member, Hartmut Hoffmann-Berling International Graduate of Molecular and Cellular Biology (HBIGS), German Excellence Initiative
2007-2010 Member, external scientific advisory board for the European Malaria Vaccine Development Association
2005-present Coordinator of the MD/PhD program at Heidelberg University
2005-2009 Member, Executive Committee, Marie-Curie Fellowship Program “MalParTraining”
2004-2009 Member, Executive Committee, European Network of Excellence “BioMalPar”
2004-2008 Member, Executive Committee, European Malaria Graduate School
1999-2002 Co-chairman of the SFB 544 “Control of Tropical Infectious Diseases
1993-present Coordinator of various EU-funded research networks (6 in total)

Pegoraro S, Duffey M, Otto TD, Wang Y, Rosemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M (2017). SC83288 is a clinical development candidate for the treatment of severe malaria. Nat Commun. 8:14193

Cyrklaff M, Srismith S, Nyboer B, Burda K, Hoffmann A, Lasitschka F, Adjalley S, Bisseye C, Simpore J, Mueller AK, Sanchez CP, Frischknecht F, Lanzer M (2016). Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat Commun. 7:13401

Rieger H, Yoshikawa HY, Quadt K, Nielsen MA, Sanchez CP, Salanti A, Tanaka M, Lanzer M (2015). Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced. Blood 125:383-391

Sanchez CP, Liu CH, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig MT, Stein WD, Lanzer M (2014). A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS genetics 10:e1004382

Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M*, Martin RE* (2014). Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter. PNAS. 111:E1759-1767; *joint senior author

Cyrklaff M, Sanchez CP, Kilian N, Bisseye C, Simpore J, Frischknecht F, Lanzer M (2011). Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes. Science 334:1283-1286

Rohrbach P, Sanchez CP, Hayton K, Friedrich O, Patel J, Sidhu AB, Ferdig MT, Fidock DA, Lanzer M (2006). Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J. 25:3000-3011

Przyborski JM, Miller SK, Pfahler JM, Henrich PP, Rohrbach P, Crabb BS, Lanzer M (2005). Trafficking of STEVOR to the Maurer’s clefts in Plasmodium falciparum-infected erythrocytes. EMBO J. 24:2306-2317

del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B, Lanzer M (2001). A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 410:839-842

Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, Pouvelle B, Gysin J, Lanzer M (1998). Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J. 17:5418-5426

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