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Universität Heidelberg,  Kommunikation und Marketing

Prof. Dr. Oliver T. Fackler

Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 1322
Fax:      +49 6221-56 5003
Email:   oliver.fackler@med.uni-heidelberg.de

FIELDS OF INTEREST

Immuno- and cell biology of HIV infection; mechanism and relevance of actin remodelling and host cell motility in HIV infection; T cell receptor signal transduction; molecular biology of diaphanous related formins.

CURRENTLY FUNDED PROJECTS

SFB638 project A11, TRR 83 project 15, GRK1188, DFG projects FA 378/6-2, FA 378/10-1, FA 378/11-1, Deutsche Krebshilfe project 109550, BMBF projects in Switch-click and Immunoquant consortia

AWARDS & HONORS

2016 Jahrespreis der Universität Heidelberg für besondere Leistungen in Forschung und Lehre
2005 Group Leader Fellowship, Chica and Heinz Schaller Foundation
2003 Habilitation in Experimental Virology at the Medical Faculty of Heidelberg University
2001 Emmy-Noether Fellowship, DFG
1999 Postdoctoral Fellowship, DFG
1998 General Accident” Insurance Award for the best thesis in the MedicalDepartment of the University of the Saarland
1997 Postdoctoral Fellowship, Howard Hughes Medical Institute

2013-present Head of section Integrative Virology, Department of Infectious Diseases, Virology, University Hospital Heidelberg
2007 W3 professor at the Department of Infectious Diseases, Virology, Heidelberg University
2003 Habilitation in Experimental Virology, Medical Faculty, Heidelberg University
2000-2007 Group leader, Department of Virology, Heidelberg University
1997-2000 Postdoctoral fellow, University of California at San Francisco
1994-1997 PhD in molecular virology (Homburg/Saar)
1993-1994 Diploma thesis in molecular virology (Homburg/Saar)
1989-1993 Studies in biology (Saarbrücken)

2015-present Coordinator SPP 1923 “Innate sensing and restriction of retroviruses”
2014-present Vice-coordinator SFB 1129 “Integrative analysis of pathogen replication and spread”
2013-present Head of section Integrative Virology, Department of Infectious Diseases, University Hospital Heidelberg
Since 2012 Member Steering Committee and Research Area D leader, second funding period cluster of excellence CellNetworks
Since 2011 Vice coordinator Heidelberg research area HIV/AIDS, DZIF, co-coordinator project “Innate and adaptive immune responses in elite controllers and acute phase HIV infection”, TTU HIV
Since 2011 Vice-chair of graduate programme 1188 (“Quantitative Analysis of DynamicProcesses in Membrane Transport and Translocation”), DFG
2007-2012 Coordinator Postdoc Programme, cluster of excellence CellNetworks
2007-2011 Chair of graduate programme 1188 (“Quantitative Analysis of DynamicProcesses in Membrane Transport and Translocation”), DFG
2005-2007 Vice-chair of graduate programme 1188 (“Quantitative Analysis of DynamicProcesses in Membrane Transport and Translocation”), DFG

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT*, Keppler OT* (2017). Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. PNAS.114:2729-2734

Kutscheidt S, Zhu R, Antoku S, Luxton GGW, Stagljar I, Fackler OT*, Gundersen G* (2014). FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement. Nat Cell Biol. 16:708-715

Fackler OT*, Murooka TT, Imle A, Mempel TR* (2014). Adding new dimensions: Towards an integrative understanding of HIV-1 spread. Nat Rev Microbiol. 12:563-574

Stolp B, Imle A, Coelho FM., Hons M, Mendiz RG, Lyck R, Stein JV*, Fackler OT* (2012). HIV-1 Nef interferes with T lymphocyte circulation through confined environments in vivo. PNAS. 109:18541–18546

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT*, Keppler OT* (2012). The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Nat Med. 18:1682-1687

Stastna J, Pan XY, Wang H, Kollmannsperger A, Kutscheidt S, Lohmann V, Grosse R, Fackler OT (2012). Differing and isoform specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation. Cell Res. 22:728–745

Pan X, Rudolph JM, Abraham L, Habermann A, Haller C, Krijnse-Locker J, Fackler OT (2012). HIV-1 Nef compensates disorganization of the immunological synapse by assembly of an intracellular Lck signalosome. Blood. 119:786-797

Stolp B, Reichman-Fried M, Abraham L, Pan X, Giese SI, Hannemann S, Goulimari P, Raz E, Grosse R, Fackler OT (2009). HIV-1 Nef interferes with host cell motility by deregulation of cofilin. Cell Host Microbe. 6:174-186

Fackler OT*, Alcover A, Schwartz O* (2007). Modulation of the immunological synapse: A key to HIV-1 pathogenesis? Nat Rev Immunol. 7:310-317

Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM (1999). Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell. 3:729-739

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