Prof. Dr. Stephan Urban

Department of Infectious Diseases, Molecular Virology (Translational Virology), Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 4902
Fax:      +49 6221-56 1946


Molecular mechanisms of Hepatitis B- and Hepatitis D Virus/host interactions with a focus on the early and late events of viral infection; Identification of hepadnaviral receptors and structural analyses of virus receptor interactions; Development of novel cell culture systems and animal models for HBV and HDV; Clinical development of entry inhibitors for HBV and HDV infection; Development of hepatotropic drugs for the therapy of liver diseases.


DFG UR72/4-3; DFG FOR1202: UR72/5-1; BMBF, Innovative Therapieverfahren, 01GU070; DFG UR72/7-1; Deutsche Krebshilfe ‘109883; BMBF, Kooperation Südkorea, 01DR12033; DZIF, TTU hepatitis TP 8.1; DZIF, flexible fonds: Myrcludex B, clinical trial; Industriekooperationen; DFG FOR1202 UR72/5-2; ZonMW, Netherlands: A human liver model for in vitro studies


2014 1. DZIF Preis
2009 Pettenkofer Preis of the Pettenkofer Foundation
2006 Stipendium of the Heinz und Chica Schaller foundation
1984-90 Studienstiftung des deutschen Volkes

2014–present Full-Professor “Translationale Virologie”
2008–2014 Professorship (apl.) at the faculty for Biosciences at the University of Heidelberg.
2001–present Independent group leader at the Department of Infectious Diseases, Molecular Virology of Heidelberg University.
2000–2001 Stipendium at the ZMBH, Heidelberg University
2000 Habilitation at the faculty for Biosciences, venia legendi molecular biology at the Ruprecht-Karls-Universität Heidelberg.
1995–2000 Postdoc Center for Molecular Biology (ZMBH), Heidelberg University (Prof. r. H. Schaller).
1991–1995 PhD, Dept. Of Virology (Prof. Dr. P. H. Hofschneider), Max-Planck-Institut für Biochemie, Martinsried
1991 Diploma in Biochemistry at the University of Tübingen

2011–present Project coordinator in the DZIF TTU Hepatitis
2008–2012 Project coordinator of the BMBF-network “Innovative Therapieverfahren

Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Kubitz R, Sültmann H, Urban S. Hepatitis B and D virus exploits sodium taurocholate co-transporting polypeptide (NTCP) for entering hepatocytes in a species-specific manner. Gastroenterology 2013 (in revision)

Meier A, Mehrle S, Weiss TS, Mier W, Urban S. The myristoylated preS1-domain of the Hepatitis B Virus L-protein mediates specific binding to differentiated hepatocytes. Hepatology. 2013 Jul;58(1):31-42.

Schieck A, Schulze A, Gähler C, Müller T, Haberkorn U, Alexandrov A, Urban S*, Mier W*. Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts. Hepatology. 2013 Jul;58(1):43-53. (*equal contribution)

Schulze A, Mills K, Weiss TS, Urban S. Hepatocyte polarization is essential for the productive entry of the hepatitis B virus. Hepatology. 2012; 55(2):373-383

Petersen J, Dandri M, Mier W, Lutgehetmann M, Volz T, von WF, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nature Biotechnology. 2008; 26:335-341

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