Dr. Alessia Ruggieri

Department of Infectious Diseases, Molecular Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 7761
Fax:      +49 6221-56 4570
Email:   alessia.ruggieri@med.uni-heidelberg.de


Molecular virology, dynamics of cellular stress and immune responses to RNA virus infection, quantitative live-cell Imaging


2014-2016        Stipendium of Chica and Heinz Schaller Foundation

2013–present Group Leader at the Department of Infectious Diseases, Molecular Virology, Heidelberg University
2008–2013 Postdoctoral at the Department of Infectious Diseases, Molecular Virology, Heidelberg University
2004–2008 Postdoctoral at the Institute of Human Genetics, University of Saarland
1999–2003 Ph.D. Virology, Ecole Normale Supérieur de Lyon, France
1998–1999 Diploma thesis, University of Lyon, France
1995–1998 Studies in Cellular and Molecular Biology Metz and Lyon, France

2017-present      Co-coordinator of the Integrated Research Training Group (IRTG) MD/PhD program at
Heidelberg/Freiburg/Munich Universities (TRR179)
2017-present      Member of steering committee TRR186, University of Heidelberg

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A (2017). Flavivirus infection uncouples translation suppression from cellular stress responses. mBio. 8:e02150-16

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R (2017). Ultrastructural characterization of Zika virus replication factories. Cell Reports 18(9):2113–2123

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Fischl W, Scaturro P, Fischer B, Ruggieri A, Bartenschlager R (2016). Dengue virus modulates mitochondrial morphodynamics through the inhibition of DRP-1 for the benefit of viral replication. Cell Host Microbe 20(3):342-56

Trotart M, Tsopoulidis N, Tibroni N, Willemsen J, Binder M, Ruggieri A, Fackler OT (2016). Sensing of HIV-1 infection in Tzm-bl cells with reconstituted expression of STING. J Virol. 90(4):2064-2076

Schmid B*, Rinas M*, Ruggieri A, Reuter A, Fischl W, Harder N, Bergeest J-P, Flossdorf M, Rohr K, Höfer T, Bartenschlager R (2015). Live-cell analysis and modeling identify determinants of attenuation of Dengue virus 2-O-methyl mutant. PLoS Pathog. 11(12):e1005345

Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A*, Bartenschlager R* (2015). Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol. 63(4):829-837      *corresponding author

Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R (2012). Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12(1):71-85

Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R (2012). Persistence of HCV in quiescent hepatic cells under conditions of an interferon-induced antiviral response. Gastroenterology 143(2):429-438

Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R (2012). Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology 56(6):2082-93

Ruggieri A, Maldener E, Sauter M, Mueller-Lantzsch N, Meese E, Fackler OT, Mayer J (2009). Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology 16:6-17

*equal contributions

Click here for further publications.