Prof. Dr. Friedrich Frischknecht

Prof. Dr. Friedrich Frischknecht

Department of Infectious Diseases, Parasitology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 6537
Fax:   +49 6221-56 4643


Cell biology and biophysics of pathogen infection, malaria cell biology, live cell imaging, cell motility


DFG “FR 2140/6-1″


2011                       ERC Starting Grant
2010                       Group Leader Fellowship, Chica and Heinz Schaller Foundation
2007                       Hengstberger Prize of Heidelberg University (with Maik Lehmann)
2004                       BioFuture Prize of the German Ministry for Education and Science
2001 / 2002          Long-term postdoctoral fellowship awards from EMBO and HFSP
2001                       Amersham Pharmacia Science Prize for Europe

2014-present Professor for Integrative Parasitology, Heidelberg University
2005-2014 Group Leader, Department of Parasitology, Heidelberg University
2001-2005 Postdoc (Insitut Pasteur, Paris, France)
2000 PhD (FU Berlin) summa cum laude
1996-2000 PhD thesis (EMBL, Heidelberg)
1995-1996 Research Student (Lab. of Molecular Biology, Cambridge, UK)
1990-1996 Biochemistry (FU Berlin)

2015-present Vice-chair and Steering Committee member of SFB 1129 “Integrative analysis of pathogen replication and spread”
2015 Co-organization of the symposium “Collective cell migration”
2010-2013 Co-organization of three EMBO courses on imaging and infection
2008 Co-organization of the symposium “Imaging host-pathogen and infection”
2005-2011 Elected member of EMBL Alumni organization
2000 Co-organization of first EMBL PhD student symposium
1999 Representative of PhD students at EMBL

Moreau CA, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz JP, Wade RC, Kursula I, Frischknecht F (2017). A unique profilin-actin interface is important for malaria parasite motility. PLoS Pathog. 13(5):e1006412

Klug D, Frischknecht F (2017). Motility precedes egress of malaria parasites from oocysts. eLife 6:e19157

Bane K, Lepper S, Kehrer J, Sattler J, Singer M, Reinig M, Heiss K, Baum J, Mueller AK, Frischknecht F (2016). The actin filament-binding protein coronin regulates motility in Plasmodium sporozoites. PLoS Pathog. 12:e1005710

Quadt, KA, Streichfuss, M, Moreau, CA, Spatz, JP, Frischknecht, F (2016). Coupling of Retrograde Flow to Force Production During Malaria Parasite Migration. ACS Nano doi: 10:2091-2102; 10.1021/acsnano.5b06417

Singer, M, Marshall, J, Heiss, K, Mair, GR, Grimm, D, Mueller, AK, Frischknecht, F (2015). Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining. Genome Biology 16:249; doi: 10.1186/s13059-015-0811-1.

Hegge S, Uhrig K, Streichfuss M, Kynast-Wolf G, Matuschewski K, Spatz JP, Frischknecht F (2012). Direct manipuation of malaria parasites with optical tweezers reveals distinct functions of Plasmodium surface proteins. ACS Nano, 2012; 6: 4648-4662.

Hellmann JK, Münter S, Kudryashev M, Schulz S, Heiss K, Müller AK, Matuschewski K, Spatz JP, Schwarz US, Frischknecht F (2011). Environmental constraints guide migration of malaria parasites during transmission. PLoS Pathogens, 2011; 7: e1002080.

Münter S, Sabass B, Selhuber-Unkel C, Kudryashev M, Hegge S, Spatz JP, Engel U, Matuschewski K, Schwarz US*, Frischknecht F* (2009). Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites. Cell Host & Microbe 2009; 6: 551-562.

Amino R*, Thiberge S, Martin B, Celli S, Shorte SL, Frischknecht F*, Ménard R* (2006). Quantitative imaging of malaria parasite transmission to the mammalian host, Nature Medicine 2006; 12:220-224.

Frischknecht F, Moreau V, Röttger S, Gonfloni S, Reckmann I, Superti-Furga G, Way M (1999). Actin-based motility of vaccinia virus mimics receptor tyrosin kinase signaling, Nature 1999; 401: 926-929.

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