Dr. Marina Lusic

Dept. of Infectious Diseases, Integrative Virology
69120 Heidelberg

Phone: +49 6221 56 5007
Fax:      +49 6221 56 5003
Email: marina.lusic@med.uni-heidelberg.de

FIELDS OF INTEREST

Nucelar organization and function, regulation of gene expression, chromatin structure, cell biology of retroviral infection, oxidative stress in viral infections

CURRENTLY FUNDED PROJECTS

DZIF Bioinformatics, DZIF TTU HIV Tenure track professorship for preclinical HIV-1 research (Infrastructure)
SFB1129, Project 20 with Martin Beck
Gilead Oxi stress and HIV-1 latency

AWARDS & HONORS

2018 Gilead Research Prize for Infectious Research
2015 Hector Stiftung Award
2009 Young Investigator Award (under 40) by the Italian Ministry of Health for Innovative Research
2007 International Mobility Scholarship by AREA Consortium, Trieste Italy
2000 ICGEB research Fellowship

2014-present Group Leader, Department of Infectious Diseases, Heidelberg University
2009-2014 Project Leader, Research Scientist, International Centre for Genetic Engineering and Biotechnology (ICGEB) Triste
2009-2014 Extended faculty member, San Raffaele Scientific Institute, Milan
2004-2008 Post-doctoral scientist in Molecular Medicine lab, ICGEB, Trieste

COST Action CA17139 European Topology Interdisciplinary Action Management Comittee

  1. Lusic M, Siliciano R F. 2016.Nuclear landscape of HIV-1 infection and integration. Nat Rev Microb. 15(2):69-82.
  2. Lucic B, Lusic M. 2016.Connecting HIV-1 integration and transcription: a step toward new treatments. FEBS Letters. 590 (13):1927
  3. Marini B, Kertesz-Farkas A, Lucic B, Hashim A, Lisek K, Manganaro L, Pongor S, Luzzati R, Mavilio F, Giacca M, Lusic M. 2015. Nuclear architecture of CD4+ T cells favors HIV-1 integration into a subset of transcriptionally active genes at the periphery of the nucleus. Nature. 14; 521 (7551): 227-31
  4. Lusic M, Giacca M. 2014. Regulation of HIV-1 latency by chromatin structure and nuclear architecture. A review article for the special issue “Functional Relevance and Dynamics of Nuclear Organization”. J Mol Biol. 2014 Jul 27
  5. Lusic M, Marini B, Ali H, Lucic B, Luzzati R, Giacca M. 2013. Proximity to PML Nuclear Bodies negatively regulates HIV-1 gene expression in CD4+ T cells. Cell Host & Microbe. 13:665-677
  6. Della Chiara G, Crotti A, Liboi E, Giacca M, Poli G, Lusic M. 2011. Negative Regulation of HIV-1 Transcription by a Heterodimeric NF-B1/p50 and C-Terminally Truncated STAT5 Complex. J Mol Biol. 2011 410 (5): 933-943
  7. Manganaro L, Lusic M*, Gutierrez MI, Cereseto A, Del Sal G, Giacca M*. 2010. Concerted action of cellular JNK and Pin-1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes. Nat Medicine. Vol 16 (3): 329-323
  8. Dieudonné M, Maiuri P, Biancotto C, Knezevich A, Kula A, Lusic M, Marcello A. 2009. Transcriptional competence of the integrated HIV-1 provirus at the nuclear periphery. EMBO J. Vol 28(15):2231-2243
  9. Perkins KJ, Lusic M, Mitar I, Giacca M, Proudfoot NJ. 2008. Transcription dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals. Molecular Cell. Vol 29 (1) 56-68
  10. Lusic M, Marcello A, Cereseto A, Giacca M. 2003. “Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter”. EMBO J. Vol 22 (24): 6550-61