Dr. Viet Loan Dao Thi

Department of Infectious Diseases, Virology
Heidelberg University Schaller Research Group
69120 Heidelberg, Germany

Phone: +49 6221-56 1328
Fax:   +49 6221-56 5003
Email: vietloan.daothi@med.uni-heidelberg.de

FIELDS OF INTEREST
Molecular virology, hepatotropic viruses, hepatitis E virus, stem cell technology, virus-host interaction, antiviral therapy and therapy resistance, protein trafficking, epithelial polarization, innate immunity, personalized medicine, liver disease

CURRENTLY FUNDED PROJECTS
Chica and Heinz Schaller Foundation group leader (2018-2023)

AWARDS & HONORS

2017-2018 Helmsley Postdoctoral fellowship at the Rockefeller University
2016 Hepatology Prize from the Swiss Association for the Study of the Liver
2015-2017 Postdoctoral fellowship from the German Research Foundation
2015-2016 Postdoctoral fellowship from the German Academic Exchange Service (declined)
2014 International Exchange Award from the Foundation of the University of Lausanne, Switzerland
2007-2010 PhD fellowship from the Cluster Infectiologie de la Région Rhône-Alpes, France

March 2018 -present Chica and Heinz Schaller research group leader at Heidelberg University
2015 – 2018 Postdoctoral fellow, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
2012 – 2014 Postdoctoral associate, Institute of Microbiology of the University Hospital Centre Vaudois and of the University of Lausanne, Lausanne, Switzerland

1. Wu X*, Dao Thi VL*, Liu P, Takacs CN, Xiang K, Andrus L, Gouttenoire J, Moradpour D, and Rice CM. Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems. In press at Gastroenterology.
2. Wu X, Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann HH, Wang Y, Vale Silva LA, Sarbanes S, Sun T, Andrus L, Quirk C, MacDonald MR, Schneider WM, An X, Rosenberg BR, and Rice CM. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. In press at Cell.
3. Takacs CN, Andreo U, Dao Thi VL, Wu X, Gleason CE, Itano MS, Spitz G, Belote RL, Flatley BR, Scull MA, Rice CM, and Simon SM. 2017. Differential egulation of lipoprotein and Hepatitis C virus secretion by Rab1b. Cell Rep. 21(2):431-441.
4. Xiang K, Michailidis E, Ding H, Peng Y, Su M, Li Y, Liu X, Dao Thi VL, Wu X, Schneider WM, Rice CM, Zhuang H, and Li T. 2016.Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA. J Hepatol. 66:288-296
5. Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D*, and Gouttenoire J*. 2016. Sofosbuvir inhibits Hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. 150:82-85
6. Morozov VA*, Dao Thi VL*, and Denner J. 2013.The transmembrane protein of the human endogenous retrovirus- K (HERV-K) modulates cytokine release and gene expression. PLoS One. 8, e70399
7. Dao Thi VL, Granier C, Zeisel MB, Guérin M, Mancip J, Granio O, Penin F, Lavillette D, Bartenschlager R, Baumert TF, Cosset FL, and Dreux M. 2012. Characterization of hepatitis C Virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. J Biol Chem. 287:31242-57
8. Molina-Jiménez F, Benedicto I, Dao Thi VL, Gondar V, Lavillette D, Marin J, Briz O, Moreno-Otero R, Aldabe R, Baumert TF, Cosset FL, López-Cabrera M, and Majano PL. 2012. Matrigelembedded 3D culture of hepatocyte-derived cell lines as a hepatocyte-like polarized system to study hepatitis C virus cycle. Virology. 425:31-39
9. Krieger SE, Zeisel MB, Davis C, Thumann C, Harris HJ, Schnober EK, Mee C, Soulier E, Royer C, Lambotin M, Grunert F, Dao Thi VL, Dreux M, Cosset FL, McKeating JA, Schuster C, and Baumert TF. 2010. Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations. Hepatology. 51 :1144-1157
10. Dreux M, Dao Thi VL, Fresquet J, Guérin M, Julia Z, Verney G, Durantel D, Zoulim F, Lavillette D, Cosset FL, and Bartosch B. 2009. Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra- and extra-cellular domains. PLoS Pathog. 5, e1000310