Prof. Dr. Ralf Bartenschlager

Molecular Virology, Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 4569
Fax:      +49 6221-56 4570


Virus – host cell interaction (esp. HCV and Dengue virus), structural and functional aspects of viral RNA replication and assembly, viral and host targets for antiviral therapy, mathematical modeling of virus replication and spread, innate immune responses and viral countermeasures, application of live cell imaging and electron microscopy methods to study the spatio-temporal regulation of the flaviviral replication cycle.


SFB/TRR 83 TP 13; SFB/TRR179 TP09, Z1; TRR209 A02; BMBF-DZIF TTU Hepatitis and Emerging Infections; BMBF-ERASysApp-SysViruDrug;  EU Marie Curie ANTIVIRALS, EU-HORIZON2020-ZIKAlliance


2017 EMBO Member
2017 Hector Science Award by the Hector Stiftung II
2016 European Virology Award
2016 Lasker-DeBakey Clinical Medical Research Award, jointly with Charles M. Rice and Michael Sofia
2015 Robert Koch Award, jointly with Charles M. Rice
2013 Lautenschläger Research Prize
2013 Member of the Deutsche Akademie der Naturforscher Leopoldina
2008 Behring Lecture
2006 Aschoff Medal from the Medical Society Freiburg
2002 William Prusoff Young Investigator Award from the International Society for Antiviral Research
2001 Löffler-Frosch Preis of the Society for Virology
2000 Robert-Koch-Förderpreis of the Bergstadt Clausthal-Zellerfeld
1991 Award for the best Ph.D. thesis from the society for molecular biological research Heidelberg

2014–present Division head “Virus-induced carcinogenesis”, German Cancer Research Center (DKFZ) Heidelberg
2002–present Full professor and head of Molecular Virology, Department of Infectious Diseases, Heidelberg University, Germany; CHS Stiftungsprofessur “Molekulare Virologie”
2000–2002 Full professor for molecular virology (C3), Institute for Virology, University of Mainz, Germany
1999–2000 Associate professor at the Institute for Virology, University of Mainz, Germany
1999 Habilitation, University of Mainz; Germany
1994–1999 Assistant professor at the Institute for Virology, University of Mainz, Germany
1991–1993 Postdoctoral research fellow at the central research unit of Hoffmann-La Roche AG, Basel, Switzerland
1990 Ph.D. in Molecular Biology, Heidelberg University, Germany
1987 Diploma thesis; Biology; Heidelberg University, Germany
1981–1987 Studies in Biology at Heidelberg University, Germany

2017–present Vice-president German Society for virology (GfV)
2016–present Member of the Chica and Heinz Schaller Foundation advisory board
2016–present Speaker DFG TRR179 “Determinants and dynamics of elimination versus persistence of hepatitis virus infection”
2014–present Coordinator Research Program Infection, Inflammation & Cancer at the German Cancer Research Center (DKFZ), Heidelberg, Germany
2013–present Co-coordinator DZIF-TTU Hepatitis
2009–2015 Speaker DFG research unit FOR 1202 “Mechanisms of persistence of hepatotropic viruses”
2008-2016 Member, DFG Fachkollegium 204 (microbiology, virology and immunology)
2008-present Member of the steering committee “CellNetworks”, Heidelberg University
2007–2011 Member of steering committee of BMBF FORSYS-Initiative ViroQuant
2005–present Coordinator of the Doctoral Study Program of the Department of Infectious Diseases and the Master/Major ‘Infectious Diseases’
2005–2009 Member of steering committee of EU research network ‘Dengue virus control’
2005–2008 Coordinator of the Forschungsschwerpunkt ‚Infection strategies of humanpathogenic viruses’ (Landesstiftung Baden-Württemberg)
2004–2009 Member of steering committee of EU network of excellence ‘virgil: antiviraldrug resistance’

Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R (2017). Deciphering the origin and evolution of Hepatitis B viruses by means of a family of new Fish Viruses. Cell Host Microbe 22:387-399

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R (2017). Ultrastructural Characterization of Zika Virus Replication Factories. Cell Rep 18:2113-2123

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R (2016). Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host Microbe 20:342-56

Seitz S, Iancu C, Volz T, Mier W, Dandri M, Urban S, Bartenschlager R (2016). A slow maturation process renders Hepatitis B virus infectious. Cell Host Microbe 20:25-35

Ruggieri A1, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G and Bartenschlager R (2012). Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Mircrobe 12:71-85

Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R (2011). Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 9:32-45

Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R (2009). Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 5:365-75

Pietschmann T, Kaul A, Koutsoudakis G, Shavinskaya A, Kallis S, Steinmann E, Abid K, Negro F, Dreux M, Cosset FL, Bartenschlager R (2006). Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl.Acad.Sci. USA 103:7408-7413

Wakita, T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R*, Liang TJ (2005). Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine 11:791-796. (*equal contribution)

Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R (1999). Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113

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