Prof. Dr. Thomas Höfer

Division of Theoretical Systems Biology
German Cancer Research Center (DKFZ)
69120 Heidelberg

Phone: +49 6221-54 51380
Fax:      +49 6221-54 51487








2017-present Associate editor, Integrative Biology
2013-present Editorial board, European Journal of Immunology
2011 Reinhart Heinrich lecture, International Study Group for Systems Biology
1994-1996 Jowett Senior Scholar, Balliol College Oxford, 1994–1996
1994 Landahl Award, Society of Mathematical Biology
1993-1996 PhD fellow, Boehringer Ingelheim Fonds

2013 – present Full professor, Heidelberg University
2011 – present Head of Division Theoretical Systems Biology, DKFZ
2007 – 2011 Group leader (tenured), DKFZ
2002 – 2006 Junior professor, theoretical biophysics, Humboldt University Berlin
2000 – 2002 Guest Scientist, Collège de France, Paris
1997 – 2002 Postdoctoral researcher, Humboldt University Berlin
1996 – 1997 Postdoctoral fellow, Max Planck Inst. for Physics of Complex Systems, Dresden

2016 – present Coordinator, European (ERA-Cosysmed) research network OPTIMIZE-NB
2013 – 2016 Coordinator, research network Immunoquant, within BMBF SysBio program
2012 – 2015 Coordinator, research network MYC-NET, within BMBF CancerSys program
2009 – 2012 Coordinator, research network EpiSys, within BMBF SysBio program
2002 – 2006 Member steering committee SFB617, Humboldt-University Berlin

1. Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Klapproth K, Rode I, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T*, Rodewald HR*. 2017. Endogenous barcoding reveals hematopoietic stem cell fates realized in vivo. Nature. in press
2. Shao C, Höfer T. 2017. Robust classification of single-cell transcriptome data by nonnegative Matrix factorization. Bioinformatics. 33:235-242
3. Schmid B, Rinas M, Ruggieri A, Acosta E, Bartenschlager M, Reuter A, Fischl W, Harder N, Bergeest JP, Flossdorf M, Rohr K, Höfer T*, Bartenschlager R*. 2015. Live cell analysis and mathematical modeling identify determinants of attenuation of Dengue virus 2’-O-methylation mutant. PLoS Path. 11: e1005345
4. Flossdorf M, Roessler J, Buchholz V, Busch D*, Höfer T*. 2015. CD8+ T cell diversification by asymmetric cell division Nat Immunol. 16:891-893
5. Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz M, Schlenner SM, Reth M, Höfer T*, Rodewald HR*. 2015. Fundamental properties of unperturbed hematopoiesis from stem cells in vivo. Nature. 518:542-546
6. Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Gräf P, Schiemann M, Höfer T*, Busch DH*. 2013. Disparate individual fates compose robust CD8+ T cell immunity. Science. 340:630-635
7. Gin E, Diernfellner ACR, Brunner M, Höfer T. 2013. The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation. Mol Syst Biol 9:667
8. Rand U, Rinas M, Schwerk J, Nöhren G, Kröger A, Kály-Kullai K, Flossdorf M, Hauser H, Höfer T*, Köster M*. 2012. Multi-layered cellular stochasticity and paracrine amplification shape the type-I interferon response. Mol Syst Biol. 8:584
9. Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, Scheffold A, Höfer T. 2010. Competing feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular microenvironments. PNAS. 107:3058–3063
10. Schulz E, Mariani L, Radbruch A, Höfer T. 2009. Sequential polarization and imprinting of Thelper type 1 differentiation by interferon-γ and interleukin-12. Immunity. 30:678-688