Joint activities from scientists in SFB1129 in Covid-19 research

We have used the lockdown period of our labs to jointly carry out extra activities in Covid-19 research. Many members of the SFB have been involved in the research efforts against SARS-CoV-2 in cooperation with partners from the University Hospital and in national and international collaborations.

Here is a collection of links (press releases, publications, interview) which document the multiple activities, as well as papers that have emerged from this work:

Publications/papers in 2020 and 2021:

  • Stanifer ML, Kee C, Cortese M, Zumaran CM, Triana S, Mukenhirn M, Kraeusslich HG, Alexandrov T, Bartenschlager R, Boulant S: Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells, Cell Rep. 2020 Jul 7; 32(1): 107863
  • Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG: Structures and distributions of SARS-CoV-2 spike proteins on intact virions, Nature 2020 Dec;588(7838):498-502. doi: 10.1038/s41586-020-2665-2. Epub 2020 Aug 17. PMID: 32805734; PMCID: PMC7116492
  • Pape C, Remme R, Wolny A, Olberg S, Wolf S, Cerrone L, Cortese M, Klaus S, Lucic B, Ullrich S, Anders-Össwein M, Wolf S, Berati C, Neufeld C, Ganter M, Schnitzler P, Merle U, Lusic M, Boulant S, Stanifer M, Bartenschlager R, Hamprecht FA, Kreshuk A, Tischer C, Kräusslich HG, Müller B, Laketa V: Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera. BioEssays 2020, e2000257. https://doi.org/10.1002/bies.202000257
  • Klein S, Mueller TG, Khalid D, Sonntag-Buck V, Heuser AM, Glass B, Meurer M, Morales I, Schillak A, Freistaedter A, Ambiel I, Winter SL, Zimmermann L, Naumoska T, Bubeck F, Kirrmaier D, Ullrich S, Barreto-Miranda I, Anders S, Grimm D, Schnitzler P, Knop M, Kraeusslich HG, Dao Thi VL, Boerner K, Chlanda P: SARS-CoV-2 RNA extraction using magnetic beads for rapid large-scale testing by RT-qPCR and RT-LAMP, Viruses 2020, 12(8), 863;  https://doi.org/10.3390/v12080863
  • Fronza R, Lusic M, Schmidt M, Lucic B: Spatial–Temporal Variations in Atmospheric Factors Contribute to SARS-CoV-2 Outbreak, Viruses 2020, 12(6), 588; https://doi.org/10.3390/v12060588, published: 27 May 2020
  • Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P: SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography, Nat Commun 11, 5885 (2020), https://doi.org/10.1038/s41467-020-19619-7
    ( Press release University Hospital Heidelberg)
  • Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R. Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies, Cell Host & Microbe 28, 853-866, 9 December 2020, https://doi.org/10.1016/j.chom.2020.11.003
    (  Press release University Hospital Heidelberg)
  • Pahmeier F, Neufeldt CJ, Cerikan B, Prasad V, Pape C, Laketa V, Ruggieri A, Bartenschlager R, Cortese M. A versatile reporter system to monitor virus infected cells and its application to Dengue virus and SARS-CoV-2 (2021). J. Virol. Vol. 95 No 4. e01715-20. https://doi.org/10.1128/JVI.01715-20
  • Tönshoff B, Müller B, Elling R, Renk H, Meissner P, Hengel H, Garbade SF, Kieser M, Jeltsch K, Grulich-Henn J, Euler J, Stich M, Chobanyan-Jürgens K, Zernickel M, Janda A, Wölfle L, Stamminger T, Iftner T, Ganzenmueller T, Schmitt C, Görne T, Laketa V, Olberg S, Plaszczyca A, Cortese M, Bartenschlager R, Pape C, Remme R, Huzly D, Panning M, Weigang S, Giese S, Ciminski K, Ankerhold J, Kochs G, Schwemmle M, Handgretinger R, Niemeyer CM, Engel C, Kern WV, Hoffmann GF, Franz AR, Henneke P, Debatin KM, Kräusslich HG (2021). Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany. JAMA Pediatr. 2021 Jun 1;175(6):586-593. doi: 10.1001/jamapediatrics.2021.0001. PMID: 33480966; PMCID: PMC7823424
  • Turoňová B, Sikora M, Schürmann C, Hagen WJH, Welsch S, Blanc FEC, von Bülow S, Gecht M, Bagola K, Hörner C, van Zandbergen G, Landry J, de Azevedo NTD, Mosalaganti S, Schwarz A, Covino R, Mühlebach MD, Hummer G, Krijnse Locker J, Beck M (2020). In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science. 2020 Oct 9;370(6513):203-208. doi: 10.1126/science.abd5223. Epub 2020 Aug 18. PMID: 32817270; PMCID: PMC7665311.
  • Tabata K, Prasad V, Paul D, Lee JY, MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V’kovski P, Hörmann K, Müller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R (2021). Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276 (2021). https://doi.org/10.1038/s41467-021-27511-1