apl. Prof. Dr. Barbara Müller

Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 1325
Fax:      +49 6221-56 5003
Email:   barbara.mueller@med.uni-heidelberg.de

FIELDS OF INTEREST

Biology of human immunodeficiency virus. Focus of current work: live-cell imaging of HIV-1 cell interactions; analysis of dynamics of HIV cell entry and HIV particle formation; HIV assembly and maturation; quantitative analysis of HIV replication steps

CURRENTLY FUNDED PROJECTS

Project 6 in SFB1129 (2 PhD students); DFG Grant MU885/5-1 (2 PhD students)

AWARDS & HONORS

1992-1997 Postdoctoral Fellowship (AIDS-Stipendienprogramm BMBF)
. .

2000–present Group leader at the Department of Infectious Diseases, Virology, Heidelberg University
2015 apl. Prof. at the Heidelberg University
2004 Habilitation in Experimental Virology (Heidelberg University)
1995–2000 Postdoctoral fellow/ research associate, Heinrich-Pette-Institute, Hamburg, Department of Cell Biology and Virology
1995 Postdoctoral fellow , German Cancer Research Center Heidelberg
1992–1995
1991–1992
Postdoctoral fellow, Fox Chase Cancer Center Philadelphia PA, USA
Postdoctoral associate, Max-Planck-Institute for Medical Research Heidelberg
1991 PhD (Dr. rer. nat.), University of Heidelberg
1988–1991 PhD thesis (Max-Planck-Institute for Medical Research Heidelberg, lab of Prof. R.S.Goody)
1987 Diploma (University of Heidelberg)
1981–1986 Study of Biology, Technical University Darmstadt and University of Heidelberg

(*equal corresponding authors)

Müller TG, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, Laketa V, Lusic M, Müller, B, and Kräusslich, HG (2021). HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. eLife Doi: 10.7554/eLife.64776

Zila V, Margiotta E, Turonova B, Müller TG, Zimmerli CE, Mattei S, Allegretti M, Börner K, Rada J, Müller B, Lusic M, Beck M and Kräusslich HG (2021). Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Cell 184, 1032-1046 e1018.

Qu K, Ke Z, Anders-Össwein M, Glass B, Mücksch F, Müller R, Schultz C, Müller B, Kräusslich HG and Briggs JAG (2021). Science, in press

Bejarano DA, Peng K, Laketa V, Börner K, Jost KL, Lucic B, Glass B, Lusic M, Müller B, and Kräusslich HG (2019). HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex. eLife, e41800.

Sakin V, Hanne J, Dunder J, Anders-Össwein M, Laketa V, Nikić I, Kräusslich HG, Lemke EA, Müller B (2017). A versatile tool for live-cell imaging and super-resolution nanoscopy studies of HIV-1 Env distribution and mobility. Cell Chem Biol. 24:635-645.e5

Schimer J, Pavova M, Anders M, Pachl P, Sacha P, Cigler P, Weber J, Majer P, Rezacova P, Kräusslich HG, Müller B*, Konvalinka J* (2015). Triggering HIV polyprotein processing inside virions by rapid photodegradation of a tight-binding photodestructable protease inhibitor. Nature Communications. 6:6461

Mattei S, Anders M, Konvalinka J, Kräusslich HG, Briggs JAG, Müller B (2014). Induced maturation of human immunodeficiency virus. J Virol. 88:13722-13731

Chojnacki J, Staudt T, Glass B, Bingen P, Engelhardt J, Anders M, Schneider J, Müller B, Hell SW, Kräusslich HG (2012). Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. 338:524-528

Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich HG, Bräuchle C, Müller B*, Lamb DC* (2011). Dynamics of HIV budding site interactions with an ESCRT component visualized in live cells. Nat Cell Biol.13:469-474

Ivanchenko S, Godinez WJ, Lampe M, Kräusslich HG, Eils R, Rohr K, Bräuchle C, Müller B*, Lamb DC* (2009). Dynamics of HIV-1 assembly and release. PLoS Pathog. 5:e1000652

Click here for a complete list of scientific publications.