Dr. Frauke Mücksch

Department of Infectious Diseases, Virology
Schaller Research Group
Heidelberg University Hospital
69120 Heidelberg, Germany

Phone: +49 6221-56 5003


Molecular virology, immuno- and cell biology of HIV infection; mechanisms of HIV latency establishment, maintenance and reversal;
molecular biology of resistance to latency reversing agents; virus-host interaction


2021                  Group Leader fellowship, CHS Stiftung
2020 – 2021     Bulgari Women & Science Fellowship in COVID-19 Research

2022-present Chica-and-Heinz Schaller group leader at Heidelberg University
2019-2022 Postdoctoral associate, The Rockefeller University, New York
2018-2019 Postdoctoral associate, Department of Virology, Heidelberg University Hospital
2013-2017 PhD student, Department of Virology, Heidelberg University Hospital
2011-2013 Studies of Biomedical Science (University of Marburg)
2008-2011 Studies of Biology (Goethe University Frankfurt)

peer-reviewed publications (*designates multiple first authors)

Muecksch F*, Wang Z*, Cho A*, Gaebler C, Ben Tanfous T, DaSilva J, Bednarski E, Ramos V, Zong S, Johnson B, Raspe R, Schaefer-Babajew D, Shimeliovich I, Daga M, Yao KH, Schmidt F, Millard KG, Turroja M, Jankovic M, Oliveira TY, Gazumyan A, Caskey M, Hatziioannou T, Bieniasz PD, Nussenzweig MC. Increased Memory B Cell Potency and Breadth After a SARS-CoV-2 mRNA Boost. Nature (2022)

Muecksch F, Wise H*, Templeton K, Batchelor B, Squires M, McCance K, Jarvis L, Malloy K, Furrie E, Richardson C, MacGuire J, Godber I, Burns A, Mavin S, Zhang F, Schmidt F, Bieniasz PD, Jenks S, Hatziioannou T. Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysis. Lancet Microbe. 2022 May 27;3(7):e493-502 (2022).

Cho A*, Muecksch F*, Schaefer-Babajew D*, Wang Z*, Finkin S*, Gaebler C, Ramos V, Cipolla M, Mendoza P, Agudelo M, Bednarski E, DaSilva E, Shimeliovich I, Dizon J, Daga M, Millard K, Turroja M, Schmidt F, Zhang F, Tanfous TB, Jankovic M, Oliveria TY, Gazumyan A, Caskey M, Bieniasz PD, Hatziioannou T, Nussenzweig MC. 2021. Anti-SARS-CoV-2 receptor binding domain antibody evolution after mRNA vaccination. Nature. https://doi.org/10.1038/s41586-021-04060-7

Muecksch F*, Weisblum Y*, Barnes CO*, Schmidt F*, Schaefer-Babajew D, Wang Z, C Lorenzi JC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD. 2021. Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity. 54:1853-1868

Wang Z*, Muecksch F*, Schaefer-Babajew D*, Finkin S*, Viant C*, Gaebler C*, Hoffmann H-H, Barnes CO, Cipolla C, Ramos V, Oliveira TY, Cho A, Schmidt F, da Silva J, Bednarski E, Aguado L, Yee J, Daga M, Turroja M, Millard KG, Jankovic M, Gazumyan A, Zhao Z, Rice CM, Bieniasz PD, Caskey M, Hatziioannou T, Nussenzweig MC. 2021. Naturally enhanced neutralizing breadth to SARS-CoV-2 one year after infection. Nature. 595:426-431

Bou-Nader C*, Muecksch F*, Brown J, Gordon JM, York A, Peng C, Ghirlando R, Summers MF, Bieniasz PD, Zhang J. 2021. Structural basis for host tRNA control of HIV-1 Gag localization. Cell Host Microbe. 29(9):1421-1436

Gaebler C*, Wang Z*, C Lorenzi JC*, Muecksch F*, Finkin S*, Tokuzama M*, Cho A*, Jankovic M*, Schaefer-Babajew D*, Oliveira TY*, Cipolla M*, Viant C, Barnes CO, Bran Y, Breton G, Haegloef T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O’Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RT, Hatiionannou T, Bjorkman PM, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. 2021. Evolution of antibody immunity to SARS-CoV-2. Nature. 591:639-644

Robbiani DF*, Gaebler C*, Muecksch F*, C Lorenzi JC*, Wang Z*, Cho A*, Agudelo M*, Barnes CO*, Gazumyan A*, Finkin S*, Hägglöf S*, Oliveira TY*, Viant C*, Hurley A, Hoffmann H-H, Millard KG, Kost RG, Cipolla M, Gordon K, Bianchini F, Chen ST, Ramos V, Patel R, Dizon J, Shimeliovich I, Mendoza P, Hartweger H, Nogueira L, Pack M, Horowitz J, Schmidt F, Weisblum Y, Michailidis E, Ashbrook AW, Waltari E, Pak JE, Huey-Tubman KE, Koranda N, Hoffman PR, West Jr AP, Rice CM, Hatziioannou T, Bjorkman PJ, Bieniasz PD, Caskey M, Nussenzweig MC. 2020. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584:437-422

Mücksch F*, Citir M*, Lüchtenborg C, Glass B, Traynor-Kaplan A, Schultz C, Brügger B, Kräusslich HG. 2019. Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes. Sci Rep 9:17661

Mücksch F, Laketa V, Müller B, Schultz C, Kräusslich HG. 2017. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. eLife 6:e2528

Click here for further publications.