Prof. Dr. Ralf Bartenschlager
Department of Infectious Diseases, Molecular Virology
Heidelberg University Hospital
69120 Heidelberg, Germany
Phone: +49 6221-56 4225
E-Mail
FIELDS OF INTEREST
Virus – host cell interaction (esp. HCV and Dengue virus), structural and functional aspects of viral RNA replication and assembly, viral and host targets for antiviral therapy, mathematical modeling of virus replication and spread, innate immune responses and viral countermeasures, application of live cell imaging and electron microscopy methods to study the spatio-temporal regulation of the flaviviral replication cycle.
AWARDS & HONORS
2022 | Ernst Jung-Preis für Medizin |
2021 | Loeffler-Lecture in the frame of the scientific symposium “111 Jahre FLI. One Health – Forschung für die Gesundheit von Mensch, Tier und Umwelt” |
2021 | M.W. Beijerinck Virology Prize of the Royal Netherlands Academy of Arts and Sciences |
2019 | Prince Mahidol Award for Medicine, Bangkok, Thailand |
2019 | McGuigan Prize for Distinguished Work in Drug Discovery |
2019 | Heinrich-Pette Lecture |
2017-2019 | Guest professor at the University of Wuhan, China |
2017 | Hector Science Award |
2017 | EMBO Member |
2016 | Hector Research Award |
2016 | European Virology Award |
2016 | Lasker-DeBakey Clinical Medical Research Award, jointly with Charles M. Rice and Michael Sofia |
2015 | Robert Koch Award, jointly with Charles M. Rice |
2013 | Lautenschläger Research Prize |
2013 | Member of the Deutsche Akademie der Naturforscher Leopoldina |
2008 | Behring Lecture |
2006 | Aschoff Medal from the Medical Society Freiburg |
2002 | William Prusoff Young Investigator Award from the International Society for Antiviral Research |
2001 | Löffler-Frosch Preis of the Society for Virology |
2000 | Robert-Koch-Förderpreis of the Bergstadt Clausthal-Zellerfeld |
1991 | Award for the best Ph.D. thesis from the society for molecular biological research Heidelberg |
. | . |
|
|||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||
Twu Woan-Ing, Lee Ji-Young, Kim Heeyoung, Prasad Vibhu, Cerikan Berati, Haselmann Uta, Tabata Keisuke, Bartenschlager Ralf. 2021, Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation. Cell Reports 37, 110049
https://doi.org/10.1016/j.celrep.2021.110049
Rastgou Talemi S, Bartenschlager M, Schmid B, Ruggieri A, Bartenschlager R, Höfer T. 2021. Dengue virus is sensitive to inhibition prior to productive replication. Cell Reports 37, 109801
Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Neufeldt C, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V’kovski P, Hörmann K, Müller A, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R. 2021. Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun. 12(1):7276 DOI: 10.1038/s41467-021-27511-1
Cortese M*, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y*, Bartenschlager R.* 2020. Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies. Cell Host Microbe. 28(6):853-866.e5. * co-corresponding authors
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R*, Chlanda P*. 2020. SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography. Nat Commun. 11(1):5885. * co-corresponding authors
Neufeldt CJ, Cortese M, Scaturro P, Cerikan B, Wideman JG, Tabata K, Moraes T, Oleksiuk O, Pichlmair A, Bartenschlager R. 2019. ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly. Nat Microbiol 4(12):2416-2429
Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. 2017. Ultrastructural Characterization of Zika Virus Replication Factories. Cell Rep. 18:2113-2123
Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. 2016. Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host Microbe. 20:342-56
Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP , Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. 2012. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Mircrobe. 12:71-85
Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. 2009. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 5:365-75
Wakita T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R*, Liang TJ. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine. 11:791-796 (*equal contribution)
Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 285:110-113
Click here for further publications.