Prof. Dr. Edward Lemke
Synthetic Biophysics of Protein Disorder
Biocentre, Departments Biology and Chemistry
Johannes Gutenberg-University Mainz
Hanns-Dieter-Hüsch-Weg 15
55128 Mainz, Germany
Phone: +49 (0)6131 39-36117
E-Mail
until 2020:
The European Molecular Biology Laboratory
(EMBL) Heidelberg
69117 Heidelberg, Germany
FIELDS OF INTEREST
Biophysics, intrinsically disordered proteins, physiochemical properties of biopolymers, single molecule/superresolution/FRET microscopy, intrinsically disordered proteins, protein structure and folding, nucleocytoplasmic shuttling, chemical biology and bioorthogonal labeling reactions
AWARDS & HONORS
| 2019 | ERC Advanced Grant (LS domain) |
| 2018 | Gutenberg Research College Fellow |
| 2017 | FEBS anniversary award |
| 2016 | Chica and Heinz Schaller award for biomedical research |
| 2015 | Young Investigator Award of the International Society for Chemical Biology |
| 2015 | ERC consolidator grant SPMFv2.0 |
| 2013 | MRN Innovation Award |
| 2010-2016 | Emmy Noether programme/group leader of the DFG |
| 2006-2008 | Feodor-Lynen postdoctoral fellowship, Alexander von Humboldt Foundation |
| 2003-2005 | PhD fellowship of the Boehringer Ingelheim Fond |
| 2002 | Erwin-Stephan award for excellent and fast studies, TU Berlin |
| 2001 | Scholarship of the German National Merit Foundation (Studienstiftung des Deutschen Volkes) until end of university studies |
| 1999-2000 | Oversea-scholarship of the Technical University of Berlin |
| 1998 | Klaus-Koch-scholarship for excellent studies, Technical University of Berlin |
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Sakin V, Hanne J, Dunder J, Anders-Osswein M, Laketa V, Nikic I, Krausslich H-G, Lemke EA, Muller B* (2017). A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility. Cell Chemical Biology 24(5):635-645.e5
Nikić I, Estrada Girona G, Kang JH, Paci G, Mikhaleva S, Koehler C, Shymanska NV, Ventura Santos C, Spitz D, Lemke EA* (2016). Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy. Angew Chem Int Ed Engl. 55(52):16172-16176
Koehler C, Sauter PF, Wawryszyn M, Estrada Girona G, Gupta K, Landry JJM, Hsi‐Yang Fritz M, Radic K, Hoffmann J-E, Chen ZA, Zou J, Tan PS, Galik B, Junttila S, Stolt‐Bergner P, Pruneri G, Gyenesei A, Schultz C, Biskup MB, Besir H, Benes V, Rappsilber J, Jechlinger M, Korbel JO, Berger I, Braese S, Lemke EA* (2016). Genetic code expansion for multiprotein complex Engineering. Nature Methods 13(12):997-1000
Milles S, Mercadante D, Aramburu IV, Jensen MR, Banterle B, Koehler C, Tyagi S, Clarke J, Shammas S, Blackledge M*, Gräter F*, Lemke EA* (2015). Plasticity of an ultrafast interaction between nucleoporin and transport receptors. Cell, 10.1016/j.cell.2015.09.047
Nikic I, Plass T, Schraidt O, Szymanski J, Briggs JA, Schultz C, Lemke EA* (2014). Dual-color super-resolution microscopy via genetic code expansion technology and tuned click reactions. Angew Chem Int Ed Engl 53(8), 2245-2249
Milles S, Bui H, Koehler C, Beck M*, Lemke EA* (2012). Facilitated aggregation propensity of FG Nucleoporins under molecular crowding conditions. EMBO Reports 14(2):178-83
Ori A, Banterle N, Iskar M, Andres-Pons A, Escher C, Bui HK, Sparks L, Mezarino VMS, Rinner O, Bork P*, Lemke EA*, Beck M* (2013). Cell-type specific nuclear pore complexes: A case in point for context-dependent stoichiometry of molecular machines. Molecular System Biology 9:648
Plass T, Milles S, Koehler C, Szymanski J, Mueller R, Schultz C*, Lemke EA* (2012). Amino acids for Diels-Alder reactions in living cells. Angew Chem Int Ed Engl 51: 4166-4170
Milles S, Tyagi S, Banterle N, Koehler C, VanDelinder V, Neal A, Lemke EA (2012). Click strategies for single-molecule protein fluorescence. J Am Chem Soc 134: 5187-5195
Plass T, Milles S, Koehler C, Schultz C*, Lemke EA* (2011). Genetically encoded copper-free click chemistry. Angew Chem Int Ed Engl 50: 3878-3881
Click here for further publications.