Prof. Dr. Michael Lanzer

Department of Infectious Diseases, Parasitology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 7845
Fax:      +49 6221-56 4643
Email:   michael.lanzer@med.uni-heidelberg.de

FIELDS OF INTEREST

Molecular parasitology, host parasite coevolution, drug resistance mechanisms of the malarial parasite; protein trafficking in P. falciparum.

CURRENTLY FUNDED PROJECTS

EU-funded Network of Excellence EVIMalaR; EU-funded PhD Programme EVIMalaR, EU-funded Infrastructure Project INFRAVEC; project within the German Center for Infection Research

AWARDS & HONORS

2011 Heidelberg Molecular Life Science Award
1995 Prize for Tropical Medicine, German Society for Tropical Medicine

2000 Offer of a Professorship at the Seattle Biomedical Institute, USA (declined)
1999-present Full Professor and head of Parasitology, Heidelberg University
1996 Habilitation in Microbiology, University of Würzburg
1994-1998 Junior group leader, Research Center for Infectious Diseases, University of Würzburg
1988-1993 PostDoc, Laboratory of Biochemical Genetics, Sloan-Kettering Institute, New York, USA
1988 PhD Biology Heidelberg University
1979-1984 Biology School (Heidelberg University)

2018-present Vice Dean, Graduate Studies, Faculty of Biosciences, Heidelberg University
2018-present Member, Faculty Board Biosciences, Heidelberg University
2018-present Member, Council for Graduate Studies, Graduate Academy, Heidelberg University
2015-present Member, Executive Board, Heidelberg Biosciences International Graduate (HBIGS), German Excellence Initiative
2014-2020 Member, ERC (European Research Council) panel “Infection & Immunity” (Starting & Consolidator Grants)
2014-present Member, External Scientific Advisory Board, European Vaccine Initiative (EVI)
2013-2016 Member, Wellcome Trust PhD Committee
2013-present Chair, External Scientific Advisory Board, ANR-funded French Alliance for Parasitology and Health Care “ParaFrap”
2012-2014 Member, Council for Graduate Studies, Graduate Academy, Heidelberg University
2010-2015 Director, international EVIMalaR PhD Programme
2008-2015 Director, European Malaria Graduate School
2008-2015 Member, Executive Committee, European Network of Excellence “EVIMalaR”
2007-2015 Director (until June 2015), ever since regular EB member, Hartmut Hoffmann-Berling International Graduate of Molecular and Cellular Biology (HBIGS), German Excellence Initiative
2007-2010 Member, External Scientific Advisory Board for the European Malaria Vaccine Development Association
2005-present Initiator and coordinator, MD/PhD program at Heidelberg University
2005-2009 Member, Executive Committee, Marie-Curie Fellowship Program “MalParTraining”
2004-2009 Member, Executive Committee, European Network of Excellence “BioMalPar”
2004-2008 Member, Executive Committee, European Malaria Graduate School
1999-2002 Co-chairman, SFB 544 “Control of Tropical Infectious Diseases

Blank A, Furle K, Jaschke A, Mikus G, Lehmann M, Husing J, Heiss K, Giese T, Carter D, Bohnlein E, Lanzer M, Haefeli WE. Bujard H (2020). Immunization with full-length Plasmodium falciparum merozoite surface protein 1 is safe and elicits functional cytophilic antibodies in a randomized first-in-human trial. NPJ Vaccines 5, p. 10

Pegoraro S, Duffey M, Otto TD, Wang Y, Rosemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M (2017). SC83288 is a clinical development candidate for the treatment of severe malaria. Nat Commun 8: 14193

Cyrklaff M, Srismith S, Nyboer B, Burda K, Hoffmann A, Lasitschka F, Adjalley S, Bisseye C, Simpore J, Mueller AK, Sanchez CP, Frischknecht F, Lanzer M. (2016). Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat Commun 7: 13401

Rieger H, Yoshikawa HY, Quadt K, Nielsen MA, Sanchez CP, Salanti A, Tanaka M, Lanzer M (2015). Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced. Blood 125: 383-391

Sanchez CP, Liu CH, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig MT, Stein WD, Lanzer M (2014). A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS genetics 10: e1004382

Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M*, Martin RE* (2014). Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter. PNAS 111: E1759-1767;

Cyrklaff M, Sanchez CP, Kilian N, Bisseye C, Simpore J, Frischknecht F, Lanzer M (2011). Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes. Science 334: 1283-1286

Rohrbach P, Sanchez CP, Hayton K, Friedrich O, Patel J, Sidhu AB, Ferdig MT, Fidock DA, Lanzer M. (2006). Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. The EMBO journal 25: 3000-3011

del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B, Lanzer M (2001). A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 410: 839-842

Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, Pouvelle B, Gysin J, Lanzer M (1998). Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. The EMBO journal 17: 5418-5426