Prof. Dr. Stephan Urban
Department of Infectious Diseases, Molecular Virology (Translational Virology)
Heidelberg University Hospital
69120 Heidelberg, Germany
Phone: +49 6221-56 4902
E-Mail
FIELDS OF INTEREST
Molecular mechanisms of Hepatitis B- and Hepatitis D Virus/host interactions with a focus on the early and late events of viral infection; Identification of hepadnaviral receptors and structural analyses of virus receptor interactions; Development of novel cell culture systems and animal models for HBV and HDV; Clinical development of entry inhibitors for HBV and HDV infection; Development of hepatotropic drugs for the therapy of liver diseases.
AWARDS & HONORS
| 2014 | Price for translational Infectious Disease Research of the German Center of Infectious Diseases (DZIF) |
| 2009 | Pettenkofer Preis of the Pettenkofer Foundation: “Neue virale Zielstrukturen” |
| 2006 | Stipendium of the Heinz und Chica Schaller foundation |
| 1984-90 | Studienstiftung des deutschen Volkes |
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Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S (2017). Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology doi:10.1002/hep.29112.
Zhang Z, Zehnder B, Damrau C, Urban S (2016). Visualization of hepatitis B virus entry – novel tools and approaches to directly follow virus entry into hepatocytes. FEBS Lett 590(13):1915-1926.
Lempp FA, Ni Y, Urban S (2016). Hepatitis delta virus: insights into a peculiar pathogen and novel treatment options. Nat Rev Gastroenterol Hepatol 13:580-589.
Bogomolov P, Alexandrov A, Voronkova N, Macievich M, Kokina K, Petrachenkova M, Lehr T, Lempp FA, Wedemeyer H, Haag M, Schwab M, Haefeli WE, Blank A, Urban S (2016). Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study. J Hepatol 65:490-498.
Urban S, Bartenschlager R, Kubitz R, Zoulim F (2014). Strategies to inhibit entry of HBV and HDV into hepatocytes. Gastroenterology 147:48-64.
Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Falth M, Stindt J, Koniger C, Nassal M, Kubitz R, Sultmann H, Urban S (2014). Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 146:1070-1083
Meier A, Mehrle S, Weiss TS, Mier W, Urban S (2013). The myristoylated preS1-domain of the Hepatitis B Virus L-protein mediates specific binding to differentiated hepatocytes. Hepatology 58(1):31-42.
Schieck A, Schulze A, Gähler C, Müller T, Haberkorn U, Alexandrov A, Urban S*, Mier W* (2013). Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts. Hepatology 58(1):43-53. (*equal contribution)
Schulze A, Mills K, Weiss TS, Urban S (2012). Hepatocyte polarization is essential for the productive entry of the hepatitis B virus. Hepatology 55(2):373-383
Petersen J, Dandri M, Mier W, Lutgehetmann M, Volz T, von WF, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S (2008). Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nature Biotechnology 26:335-341
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