Prof. Dr. Friedrich Frischknecht
Department of Infectious Diseases, Parasitology
Heidelberg University Hospital
69120 Heidelberg, Germany
Phone: +49 6221-56 6537
E-Mail
FIELDS OF INTEREST
Cell biology and biophysics of pathogen infection, malaria cell biology, live cell imaging, cell motility
AWARDS & HONORS
2011 ERC Starting Grant
2010 Group Leader Fellowship, Chica and Heinz Schaller Foundation
2007 Hengstberger Prize of Heidelberg University (with Maik Lehmann)
2004 BioFuture Prize of the German Ministry for Education and Science
2001 / 2002 Long-term postdoctoral fellowship awards from EMBO and HFSP
2001 Amersham Pharmacia Science Prize for Europe
| 2014-present | Professor for Integrative Parasitology, Heidelberg University |
| 2005-2014 | Group Leader, Department of Parasitology, Heidelberg University |
| 2001-2005 | Postdoc, Department of Parasitology, Insitut Pasteur, Paris, France |
| 2000 | PhD (FU Berlin) summa cum laude |
| 1996-2000 | PhD thesis (EMBL, Heidelberg) |
| 1995-1996 | Research Student (Lab. of Molecular Biology, Cambridge, UK) |
| 1990-1996 | Biochemistry (FU Berlin) |
| 2020-2023 | Co-director “Biology of Parasitism” course, Woods Hole, USA |
| 2020-present | Steering Committee member of SPP 2225 “Exit strategies of intracellular pathogens” |
| 2014-present | Vice-chair and Steering Committee member of SFB 1129 “Integrative analysis of pathogen replication and spread” |
| 2015 | Co-organization of the symposium “Collective cell migration” |
| 2010-2013 | Co-organization of three EMBO courses on imaging and infection |
| 2008 | Co-organization of the symposium “Imaging host-pathogen and infection” |
| 2005-2011 | Elected member of EMBL Alumni organization |
| 2000 | Co-organization of first EMBL PhD student symposium |
| 1999 | Representative of PhD students at EMBL |
(*designates multiple corresponding authors)
Klug D*, Goellner S, Kehrer J, Sattler JM, Strauss L, Singer M, Lu C, Springer TA* and Frischknecht F*, Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP, eLife, 9 e57572, 2020.
Spreng B, Fleckenstein H, Kübler P, di Biagio C, Benz M, Patra P, Schwarz US, Cyrklaff M, Frischknecht F. 2019. Microtubule number and length determine cellular shape and function of Plasmodium. EMBO J. 38:e100984
Klug D*, Frischknecht F*. 2017. Motility precedes egress of malaria parasites from oocysts. eLife. 6:e19157
Quadt K, Streichfuss M, Moreau C, Spatz, JP, Frischknecht F. 2016. Coupling of retrograde flow to force production during malaria parasite migration. ACS Nano. 10:2091-2102
Singer M*, Marshall J, Heiss K, Mair GR, Grimm D, Mueller AK, Frischknecht F*. 2015. Zinc-finger nuclease-based double strand breaks attenuate malaria parasites and reveal rare micro-homology mediated end joining. Genome Biol. 16:249
Hellmann JK, Münter S, Kudryashev M, Schulz S, Heiss K, Müller AK, Matuschewski K, Spatz JP, Schwarz US, Frischknecht F. 2011. Environmental constraints guide migration of malaria parasites during transmission. PLoS Pathog. 7:e1002080
Münter S, Sabass B, Selhuber-Unkel C, Kudryashev M, Hegge S, Spatz JP, Engel U, Matuschewski K, Schwarz US*, Frischknecht F*. 2009. Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites. Cell Host Microbe. 6:551-562
Cyrklaff M*, Kudryashev M, Leis A, Leonard K, Baumeister W, Ménard R, Meissner M, Frischknecht F*. 2007. Cryoelectron tomography reveals periodic luminal material in subpellicular microtubules from apicomplexan parasites. J. Exp. Med. 204:1281-1287
Amino R*, Thiberge S, Martin B, Celli S, Shorte SL, Frischknecht F* , Ménard R*. 2006. Quantitative imaging of malaria parasite transmission to the mammalian host. Nat. Med. 12:220-224
Frischknecht F, Moreau V, Röttger S, Gonfloni S, Reckmann I, Superti-Furga G, Way M. 1999. Actin-based motility of vaccinia virus mimics receptor tyrosin kinase signaling. Nature. 401:926-9
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