Dr. Viet Loan Dao Thi

Department of Infectious Diseases – Virology
Heidelberg University Hospital, Schaller Research Group
69120 Heidelberg, Germany

Phone: +49 6221-56 1328
E-Mail

FIELDS OF INTEREST

Molecular virology, hepatotropic viruses, hepatitis E virus, stem cell technology, virus-host interaction, antiviral therapy and therapy resistance, protein trafficking, epithelial polarization, innate immunity, personalized medicine, liver disease

AWARDS & HONORS

2017-2018 Helmsley Postdoctoral fellowship at the Rockefeller University
2016 Hepatology Prize from the Swiss Association for the Study of the Liver
2015-2017 Postdoctoral fellowship from the German Research Foundation
2015-2016 Postdoctoral fellowship from the German Academic Exchange Service (declined)
2014 International Exchange Award from the Foundation of the University of Lausanne, Switzerland
2007-2010 PhD fellowship from the Cluster Infectiologie de la Région Rhône-Alpes, France

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04/2018 -present Chica and Heinz Schaller research group leader at Heidelberg University
2015 – 2018 Postdoctoral fellow, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
2012 – 2014 Postdoctoral associate, Institute of Microbiology of the University Hospital Centre Vaudois and of the University of Lausanne, Lausanne, Switzerland
2021 – Member of Heidelberg University Research Council
2021 – Member Steering Committee SFB 1129 Pathogen Replication and Spread
2019 – Member of “DZIF Academy” at partner site Heidelberg

* Equal contribution, † corresponding authorship

Maurer L, El Andari J, Rapti K, Spreyer L, Steinmann E, Grimm D, Dao Thi VL. 2022. Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector. Viruses 2022, 14, 266. https://doi.org/10.3390/v14020266

Zhang C, Freistaedter A, Schmelas C, Gunkel M, Dao Thi VL†* and Grimm D†*. 2021. A novel RNA interference/Adeno-associated virus vector combinatorial gene therapy approach against hepatitis E virus. Hepatol Commun. 0:1-11

Dao Thi VL†, Herbst K, Boerner K, Meurer M, Kremer PML, Kirrmaier D, Freistaedter A, Papagiannidis D, Galmozzi C, Stanifer ML, Boulant S, Klein S, Chlanda P, Khalid D, Barreto Mirranda I, Schnitzler P, Kräusslich HG, Knop M, and Anders S. 2020. A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples. Sci Transl Med. 12(556):eabc7075

Dao Thi VL†, Wu X, Belote RL, Andreo U, Takacs CN, Fernandez JP, Vale-Silva LA, Decker CC, Fu RM, Qu B, Uryu K, Molina H, Saeed M, Steinmann E, Urban S, Singarja RR, Schneider WM, Simon SM, and Rice CM. 2020. Stem cell-derived polarized hepatocytes. Nature Commun. 11(1):1677

Fu RM, Decker CC, and Dao Thi VL†. 2019. Cell Culture Models for Hepatitis E Virus. Viruses 11(7):608

Gouttenoire J, Pollán A, Abrami L, Oechslin N, Mauron J, Matter M, Oppliger J, Szkolnicka D, Dao Thi VL, van der Goot FG, and Moradpour D. 2018. Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion. PLoS Pathog.10;14(12):e1007471

Chung H, Calis JJA, Wu X, Sun T, Yu Y, Sarbanes SL, Dao Thi VL, Shilvock AR, Hoffmann HH, Rosenberg BR, and Rice CM. 2018. Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown. Cell. 172(4):811-824

Wu X*, Dao Thi VL*, Liu P, Takacs CN, Xiang K, Andrus L, Gouttenoire J, Moradpour D, and Rice CM. 2018. Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems. Gastroenterology. 154(3):663-647

Wu X, Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann HH, Wang Y, Vale Silva LA, Sarbanes S, Sun T, Andrus L, Quirk C, MacDonald MR, Schneider WM, An X, Rosenberg BR, and Rice CM. 2018. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 172(3):423-438

Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D*, and Gouttenoire J*. 2016. Sofosbuvir inhibits Hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. 150:82-85

Dao Thi VL, Granier C, Zeisel MB, Guérin M, Mancip J, Granio O, Penin F, Lavillette D, Bartenschlager R, Baumert TF, Cosset FL, and Dreux M. 2012. Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. J Biol Chem. 287:31242-57

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