Universität Heidelberg,  Kommunikation und Marketing

Prof. Dr. Oliver T. Fackler

Department of Infectious Diseases, Integrative Virology
Heidelberg University Hospital
69120 Heidelberg, Germany

Phone: +49 6221-56 1322


Immuno- and cell biology of HIV infection; mechanism and relevance of actin remodelling and host cell motility in HIV infection; T cell receptor signal transduction; molecular biology of diaphanous related formins.



2016 Jahrespreis der Universität Heidelberg für besondere Leistungen in Forschung und Lehre
2005 Group Leader Fellowship, Chica and Heinz Schaller Foundation
2003 Habilitation in Experimental Virology at the Medical Faculty of Heidelberg University
2001 – 2004 Emmy-Noether Fellowship for an independent junior research group, DFG
1999 – 2000 Postdoctoral fellowship, DFG
1997 – 1999 Postdoctoral fellowship, Howard Hughes Medical Institute
1998 General Accident” Insurance Award for the best thesis in the Medical Department of the University of the Saarland
2013-present Head of section Integrative Virology, Department of Infectious Diseases, Virology, University Hospital Heidelberg
2007 W3 professor at the Department of Infectious Diseases, Virology, Heidelberg University
2003 Habilitation in Experimental Virology, Medical Faculty, Heidelberg University
2000-2007 Group leader, Department of Virology, Heidelberg University
1997-2000 Postdoctoral fellow, University of California at San Francisco
1994-1997 PhD in molecular virology (Homburg/Saar)
1993-1994 Diploma thesis in molecular virology (Homburg/Saar)
1989-1993 Studies in biology (Saarbrücken)
2021 – present Heidelberg research area HIV/AIDS, DZIF
2015 – present Coordinator SPP 1923 “Innate sensing and restriction of retroviruses”
2014 – present Vice-coordinator SFB 1129 “Integrative analysis of pathogen replication and spread”
2012 – 2020 Member Steering Committee, cluster of excellence CellNetworks
2011 – 2020 Vice coordinator Heidelberg research area HIV/AIDS, DZIF, co-coordinator project “Innate and adaptive immune responses in elite controllers and acute phase HIV infection”, TTU HIV
2011 – 2014 Vice-chair of graduate programme 1188 (“Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation”), DFG
2007 – 2012 Coordinator Postdoc Programme, cluster of excellence CellNetworks
2007 – 2010 Chair of the graduate programme 1188 (“Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation”), DFG
2005 – 2007 Vice-chair of graduate programme 1188 (“Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation”), DFG

(*designates multiple corresponding authors)

Stolp B, Stern M, Ambiel I, Hofmann K, Morath K, Gallucci L, Cortese M, Bartenschlager R, Ruggieri A, Graw F, Rudelius M, Keppler OT, Fackler OT (2022). SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models. Cell Reports 38, 110387, February 15, 2022,

Kaw S, Ananth S, Tsopoulidis N, Morath K, Coban BM, Hohenberger R, Bulut OC, Klein F, Stolp B, Fackler OT .(2020). HIV-1 infection of CD4 T cells impairs antigen-specific B cell function. EMBO J. 39: e105594.

Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R, Fackler OT (2019). T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions. Sci Immunol. 4: eaav1987.

Imle A, Kumberger P, Schnellbächer N, Fehr J, Carillo-Bustamante P, Ales J, Schmidt P, Ritter C, Godinez WJ, Müller B, Rohr K, Hamprecht FA, Schwarz U, Graw F, Fackler OT. (2019). Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures. Nat. Comm. 10:2144

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT*, Keppler OT* (2017). Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. PNAS.114:2729-2734

Imle A, Abraham L, Tsopoulidis N, Hoflack B, Saksela K, Fackler OT (2015). Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with Exocyst. mBio 6: e01309-15

Kutscheidt S, Zhu R, Antoku S, Luxton GGW, Stagljar I, Fackler OT*, Gundersen G* (2014). FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement. Nat Cell Biol. 16:708-715

Fackler OT*, Murooka TT, Imle A, Mempel TR* (2014). Adding new dimensions: Towards an integrative understanding of HIV-1 spread. Nat Rev Microbiol. 12:563-574

Stolp B, Imle A, Coelho FM., Hons M, Mendiz RG, Lyck R, Stein JV*, Fackler OT* (2012). HIV-1 Nef interferes with T lymphocyte circulation through confined environments in vivo. PNAS. 109:18541–18546

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT*, Keppler OT* (2012). The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Nat Med. 18:1682-1687

Stolp B, Reichman-Fried M, Abraham L, Pan X, Giese SI, Hannemann S, Goulimari P, Raz E, Grosse R, Fackler OT (2009). HIV-1 Nef interferes with host cell motility by deregulation of cofilin. Cell Host Microbe. 6:174-186

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