Prof. Dr. Thomas Höfer

Division of Theoretical Systems Biology
German Cancer Research Center (DKFZ)
69120 Heidelberg

Phone: +49 6221-42 1980


mathematical modeling, innate and adaptive immune responses, virus replication


2021-2024 Visiting professor, University of Oxford
since 2020 Fellow, Berlin-Brandenburg Academy of Sciences and Humanities
since 2019 Editorial board member, Cell Systems
2019-2020 Visiting professor, Ecole normale supérieure, Paris
2013-2020 Editorial board member, European Journal of Immunology
2011 Reinhart Heinrich lecture, International Study Group for Systems Biology
1994-1996 Jowett Senior Scholar, Balliol College Oxford
1994 Landahl Award, Society of Mathematical Biology
1993-1996 PhD fellow, Boehringer Ingelheim Fonds
2013 – present Full professor, Heidelberg University
2011 – present Head of Division Theoretical Systems Biology, DKFZ
2007 – 2011 Group leader (tenured), DKFZ
2002 – 2006 Junior professor, theoretical biophysics, Humboldt University Berlin
2000 – 2002 Guest Scientist, Collège de France, Paris
1997 – 2002 Postdoctoral researcher, Humboldt University Berlin
1996 – 1997 Postdoctoral fellow, Max Planck Inst. for Physics of Complex Systems, Dresden
2020 – present Coordinator, European research consortium INFER-NB (funded by ERA CoSysMed)
2016 – present Coordinator, European (ERA-Cosysmed) research network OPTIMIZE-NB
2013 – 2016 Coordinator, research network Immunoquant, within BMBF SysBio program
2012 – 2015 Coordinator, research network MYC-NET, within BMBF CancerSys program
2009 – 2012 Coordinator, research network EpiSys, within BMBF SysBio program
2002 – 2006 Member steering committee SFB617, Humboldt-University Berlin

(*equal corresponding authors)

Rastgou Talemi S, Bartenschlager M, Schmid B, Ruggieri A, Bartenschlager R, Höfer T. 2021. Dengue virus is sensitive to inhibition prior to productive replication. Cell Reports 37, 109801

Pei W, Shang F, Wang X, Fanti AK, Greco A, Busch K, Klapproth K, Zhang Q, Quedenau C, Sauer S, Feyerabend TB, Höfer T*, Rodewald HR* (2020). Resolving fates and single-cell transcriptomes of hematopoietic stem cell clones by PolyloxExpress barcoding. Cell Stem Cell 27, 383-395.

Kuchen EE, Becker NB, Claudino N, Höfer T (2020). Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees. eLife 9:e51002.

Körber V, Yang J, Barah P, Wu Y, Stichel D, Gu Z, Fletcher MNC, Jones D, Hentschel B, Lamszus K, Tonn JC, Schackert G, Sabel M, Felsberg J, Zacher A, Kaulich K, Hübschmann D, Herold-Mende C, von Deimling A, Weller M, Radlwimmer B, Schlesner M, Reifenberger G*, Höfer T*, Lichter P* (2019). Evolutionary trajectories of IDH-WT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. Cancer Cell 35, 692-704

Li C, Cesbron F, Oehler M, Brunner M, Höfer T (2018). Frequency modulation of transcriptional bursting enables sensitive and rapid gene regulation. Cell Systems, 6, 409-423.

Ryl T, Kuchen EE, Bell E, Shao C, Floréz A, Moenke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T (2017). Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug. Cell Systems 5, 237-250.

Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Klapproth K, Rode I, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T*, Rodewald HR* (2017). Endogenous barcoding reveals hematopoietic stem cell fates realized in vivo. Nature 548, 456-460

Flossdorf M, Roessler J, Buchholz V, Busch D*, Höfer T* (2015). CD8+ T cell diversification by asymmetric cell division. Nature Immunology 16, 891-893.

Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz M, Schlenner SM, Reth M, Höfer T*, Rodewald HR* (2015). Fundamental properties of unperturbed hematopoiesis from stem cells in vivo. Nature 518, 542-546.

Buchholz VR#, Flossdorf M#, Hensel I, Kretschmer L, Gräf P, Schiemann M, Höfer T*, Busch DH* (2013). Disparate individual fates compose robust CD8+ T cell immunity. Science 340, 630-635.

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