Dr. Marina Lusic

Department of Infectious Diseases, Integrative Virology
Heidelberg University Hospital
69120 Heidelberg, Germany

Phone: +49 6221 56 5007
Fax:      +49 6221 56 5003
Email: marina.lusic@med.uni-heidelberg.de


Nucelar organization and function, regulation of gene expression, chromatin structure, cell biology of retroviral infection, oxidative stress in viral infections


2018 Gilead Research Prize for Infectious Research
2015 Hector Stiftung Award
2009 Young Investigator Award (under 40) by the Italian Ministry of Health for Innovative Research
2007 International Mobility Scholarship by AREA Consortium, Trieste Italy
2000 ICGEB research Fellowship
2014-present DZIF Group Leader, Department of Infectious Diseases, Heidelberg University
2009-2014 Project Leader, Research Scientist, International Centre for Genetic Engineering and Biotechnology (ICGEB) Triste
2009-2014 Extended faculty member, San Raffaele Scientific Institute, Milan
2004-2008 Post-doctoral scientist in Molecular Medicine lab, ICGEB, Trieste
COST Action CA17139 European Topology Interdisciplinary Action Management Comittee

Shytaj IL, Procopio FA, Tarek M, Carlon -Andres I, Tang H-Y, Goldman, AR, Munshi, M H, Forcato M, Leskov K, Ye F, Lucic B, Cruz N, Singh A, Bicciato S, Padilla-Parra S, Diaz RS, Lusic M, Karn J, Alvarez-Carbonell D, Savarino A. 2021. Glycolysis downregulation is a hallmark of HIV-1 latency and sensitized infected cells to oxidative stress. EMBO Mol Med. 2021 Aug 9;13(8):e13901

Müller TG, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, Laketa V, Lusic M, Müller B, Kräusslich H-G. 2021. HIV-1 Uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. eLIFE 2021

Zila V, Margiotta E, Turonova B, Müller TG, Zimmerli C, Mattei S, Allegretti M, Borner K, Rada J, Müller B, Lusic M, Kräusslich HG, Beck M. 2021. Cone-shaped HIV-1 Capsids are transported through intact nuclear pores. Cell 2021 184, 1-15

Shytaj IL, Lucic B, Forcato M, Penzo, C, Billingsley J, Laketa, V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese K, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A and Lusic M. 2020. Alterations of redox and iron metabolism accompany development of HIV latency. EMBO J 2020 May 4, 39(9)

Lucic B, Chen H-C, Kuzman M, Zorita E, Wegner J, Minneker V, Wang W, FronzaR, Laufs S, Schmidt M, Stadhouders R, Roukos V, Vlahovicek K, Filion GJ and Lusic M. 2019. Spatially clustered loci with multiple enhancers are frequent targets of HIV-1. Nature Commun 2019 Sept; 10(1):4059

Michieleto D, Lusic M, Orlandini E, Marenduzzo D. 2019. Physical principles of retroviral integration. Nat Commun. 2019 Feb 4;10(1):575. doi: 10.1038/s41467-019-08333-8

Bejarano DA, Peng K, Laketa V, Börner K, Jost KL, Lucic B, Glass B, Lusic M, Müller B, Kräusslich HG. 2019. HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. Elife. 2019 Jan 23;8. IF 7,616

Lusic M and Siliciano R F. 2016.Nuclear landscape of HIV-1 infection and integration. Nat Rev Microb. 15(2):69-82

Marini B, Kertesz-Farkas A, Lucic B, Hashim A, Lisek K, Manganaro L, Pongor S, Luzzati R, Mavilio F, Giacca M and Lusic M. 2015. Nuclear architecture of CD4+ T cells favors HIV-1 integration into a subset of transcriptionally active genes at the periphery of the nucleus. Nature. 14; 521 (7551): 227-31

Lusic M, Marini B, Ali H, Lucic B, Luzzati R, and Giacca M. 2013. Proximity to PML Nuclear Bodies negatively regulates HIV-1 gene expression in CD4+ T cells. Cell Host & Microbe. 13: 665-677

Click here for further publications.