Dr. Marina Lusic

Dept. of Infectious Diseases, Integrative Virology
69120 Heidelberg

Phone: +49 6221 56 5007
Fax:      +49 6221 56 5003
Email: marina.lusic@med.uni-heidelberg.de

FIELDS OF INTEREST

Nucelar organization and function, regulation of gene expression, chromatin structure, cell biology of retroviral infection, oxidative stress in viral infections

CURRENTLY FUNDED PROJECTS

DZIF Bioinformatics, DZIF TTU HIV Tenure track professorship for preclinical HIV-1 research (Infrastructure)
SFB1129, Project 20 with Martin Beck
Gilead Oxi stress and HIV-1 latency

AWARDS & HONORS

2018 Gilead Research Prize for Infectious Research
2015 Hector Stiftung Award
2009 Young Investigator Award (under 40) by the Italian Ministry of Health for Innovative Research
2007 International Mobility Scholarship by AREA Consortium, Trieste Italy
2000 ICGEB research Fellowship

2014-present Group Leader, Department of Infectious Diseases, Heidelberg University
2009-2014 Project Leader, Research Scientist, International Centre for Genetic Engineering and Biotechnology (ICGEB) Triste
2009-2014 Extended faculty member, San Raffaele Scientific Institute, Milan
2004-2008 Post-doctoral scientist in Molecular Medicine lab, ICGEB, Trieste

COST Action CA17139 European Topology Interdisciplinary Action Management Comittee

Lucic B, de Castro IJ, Lusic M (2021). Viruses in the Nucleus Cold Spring Harb Perspect Biol 2021 Mar 22L a039446 doi: 10.1101/cshperspect.a039446

Shytaj IL, Lucic B, Forcato M, Penzo, C, Billingsley J, Laketa, V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese K, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A and Lusic M (2020). Alterations of redox and iron metabolism accompany development of HIV latency. EMBO J. May 4, 39(9)

Lucic B, Chen H-C, Kuzman M, Zorita E, Wegner J, Minneker V, Wang W, FronzaR, Laufs S, Schmidt M, Stadhouders R, Roukos V, Vlahovicek K, Filion GJ and Lusic M (2019). Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 Nature Commun, Sept; 10(1):4059

Michieleto D, Lusic M, Orlandini E, Marenduzzo D (2019). Physical principles of retroviral integration. Nat Commun, Feb 4;10(1):575. doi: 10.1038/s41467-019-08333-8

Lusic M and Siliciano R F. (2016). Nuclear landscape of HIV-1 infection and integration. Nat Rev Microb. 15(2):69-82.

Lucic B and Lusic M (2016). Connecting HIV-1 integration and transcription: a step toward new treatments. FEBS Letters. 590 (13):1927

Marini B, Kertesz-Farkas A, Lucic B, Hashim A, Lisek K, Manganaro L, Pongor S, Luzzati R, Mavilio F, Giacca M and Lusic M (2015). Nuclear architecture of CD4+ T cells favors HIV-1 integration into a subset of transcriptionally active genes at the periphery of the nucleus. Nature. 14; 521 (7551): 227-31

Lusic M, Marini B, Ali H, Lucic B, Luzzati R, and Giacca M (2013). Proximity to PML Nuclear Bodies negatively regulates HIV-1 gene expression in CD4+ T cells. Cell Host & Microbe. 13: 665-677