Dr. John A.G. Briggs

Max-Planck-Institut für Biochemie
Virale und Zelluläre Strukturbiologie
Am Klopferspitz 18
82152 Martinsried

Tel:
Email: 

until September 2021:

Medical Research Council Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge CB2 0QH
United Kingdom
Tel: +44 1223 267245
Email: jbriggs@mrc-lmb.cam.ac.uk

FIELDS OF INTEREST

Enveloped virus structure, assembly and budding, cellular vesicle budding mechanisms, cryo-electron tomography methods, correlative light and electron microscopy methods.

CURRENTLY FUNDED PROJECTS

DFG BR 3635/2-1 “Die Struktur des assemblierten, unreifen Gag-Proteinnetzwerks von Retroviren”
ERC Consolidator grant ERC-2014-CoG 648432. “Structure and mechanism of viral and cellular membrane fusion machineries”
EU project 653706 – iNEXT. “Infrastructure for NMR, EM and X-ray crystallography for translational research”

AWARDS & HONORS

2012 Chica and Heinz Schaller Research Award
2014 Yale University Sears Lecture
2015 Royal Microscopical Society Medal for Life Sciences
2015 Elected to EMBO Membership
2015 Ernst-Ruska prize for outstanding achievements in electron microscopy
2018 Blavatnik Awards UK Finalist

2021-present Director, Dept. Cell and Virus Structure, MPI of Biochemistry, Martinsried
2017-2021 Programme Leader, Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K.
2013-2016 Senior Scientist, European Molecular Biology Laboratory
2006-2016 Group Leader – Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
2005-2006 Postdoctoral Research Fellow, Ludwig Maximilians University Munich, Germany
2004 Postdoctoral Scientist, Oxford University, U.K.
2000 – 2004 D.Phil. in Structural Biology, Oxford University, U.K
1996 – 2000 Bachelor (B.A.) and Master (M.Sci.) in Natural Sciences (Biochemistry) Cambridge University
2017 – present Institut de Biologie Structurale Grenoble scientific advisory board member
2016 – present FEBS Letters editorial board member
2015 – present Max-Planck Institute of Molecular Cell Biology and Genetics scientific advisory board member
2013 France-BioImaging scientific advisory board member
2009 – present Electron Microscopy Core Facility Committee Member
2008 – present Graduate Program Committee Member
2008 – 2011 Science & Society Committee Member

Peukes, J., Xiong, X., Erlendsson, S., Qu, K., Wan, W., Calder, L.J., Schraidt, O., Kummer, S., Freund, S.M.V., Kräusslich, H.G., Briggs, J.A.G. (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature 587(7834): 495–498.

Ke, Z., Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt, C.J., Cerikan, B., Lu, J.M., Peukes, J., Xiong, X., Kräusslich, H.G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature 588(7838): 498–502.

Kovtun, O., Leneva, N., Bykov, Y.S., Ariotti, N., Teasdale, R.D., Schaffer, M., Engel, B.D., *Owen, D.J., *Briggs, J.A.G., *Collins, B.M. (2018). Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature 561(7724): 561-564.

Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G. (2017). Structure and assembly of the Ebola virus nucleocapsid. Nature 551: 394-397

Mattei, S., Glass, B., Hagen, W.J., Kräusslich, H.G. and Briggs, J.A. (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 6318: 1434-1437

Schur, F.K., Obr, M., Hagen, W.J., Wan, W., Jakobi, A.J., Kirkpatrick, J.M., Sachse, C., Kräusslich, H.G. and Briggs, J.A. (2016). An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Science 353(6298): 506-508

Dodonova, S.O., Diestelkoetter-Bachert, P., von Appen, A., Hagen, W.J., Beck, R., Beck, M., Wieland, F. and Briggs, J.A. (2015). A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly. Science 349(6244): 195-198

Avinoam, O., Schorb, M., Beese, C.J., *Briggs, J.A. and *Kaksonen, M. (2015). Endocytic sites mature by continuous bending and remodeling of the clathrin coat. Science 348(6241): 1369-1372

Schur, F.K., Hagen, W.J., Rumlová, M., Ruml, T., Müller, B., Kräusslich, H.G. and Briggs, J.A. (2015). Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution. Nature 517(7535): 505-508

Bharat, T.A., Davey, N.E., Ulbrich, P., Riches, J.D., de Marco, A., Rumlova, M., Sachse, C., Ruml, T., Briggs, J.A. (2012). Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy. Nature 487(7407): 385-389

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