Dr. John A.G. Briggs

Department of Cell and Virus Structure
Max-Planck-Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried, Germany

phone: +49 89 8578 2592
E-Mail

FIELDS OF INTEREST

Enveloped virus structure, assembly and budding, cellular vesicle budding mechanisms, cryo-electron tomography methods,
correlative light and electron microscopy methods.

AWARDS & HONORS

2018      Blavatnik Awards UK Finalist
2015      Ernst-Ruska prize for outstanding achievements in electron microscopy
2015      Elected to EMBO Membership
2015      Royal Microscopical Society Medal for Life Sciences
2014      Yale University Sears Lecture
2012      Chica and Heinz Schaller Research Award

2021-present Director, Dept. Cell and Virus Structure, MPI of Biochemistry, Martinsried
2017-2021 Programme Leader, Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K.
2013-2016 Senior Scientist, European Molecular Biology Laboratory
2006-2016 Group Leader – Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
2005-2006 Postdoctoral Research Fellow, Ludwig Maximilians University Munich, Germany
2004 Postdoctoral Scientist, Oxford University, U.K.
2000 – 2004 D.Phil. in Structural Biology, Oxford University, U.K
1996 – 2000 Bachelor (B.A.) and Master (M.Sci.) in Natural Sciences (Biochemistry) Cambridge University

Qu K, Ke Z, Zila V, Anders-Össwein M, Glass B, Mücksch F, Müller R, Schultz C, Müller B, Kräusslich HG, Briggs JAG. 2021. Maturation of the matrix and viral membrane of HIV-1. Science 373(6555): 700-704

Peukes, J., Xiong, X., Erlendsson, S., Qu, K., Wan, W., Calder, L.J., Schraidt, O., Kummer, S., Freund, S.M.V., Kräusslich, H.G., Briggs, J.A.G. (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature 587(7834): 495–498.

Ke, Z., Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt, C.J., Cerikan, B., Lu, J.M., Peukes, J., Xiong, X., Kräusslich, H.G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature 588(7838): 498–502.

Kovtun, O., Leneva, N., Bykov, Y.S., Ariotti, N., Teasdale, R.D., Schaffer, M., Engel, B.D., *Owen, D.J., *Briggs, J.A.G., *Collins, B.M. (2018). Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature 561(7724): 561-564.

Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G. (2017). Structure and assembly of the Ebola virus nucleocapsid. Nature 551: 394-397

Mattei, S., Glass, B., Hagen, W.J., Kräusslich, H.G. and Briggs, J.A. (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science 6318: 1434-1437

Schur, F.K., Obr, M., Hagen, W.J., Wan, W., Jakobi, A.J., Kirkpatrick, J.M., Sachse, C., Kräusslich, H.G. and Briggs, J.A. (2016). An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Science 353(6298): 506-508

Dodonova, S.O., Diestelkoetter-Bachert, P., von Appen, A., Hagen, W.J., Beck, R., Beck, M., Wieland, F. and Briggs, J.A. (2015). A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly. Science 349(6244): 195-198

Avinoam, O., Schorb, M., Beese, C.J., *Briggs, J.A. and *Kaksonen, M. (2015). Endocytic sites mature by continuous bending and remodeling of the clathrin coat. Science 348(6241): 1369-1372

Schur, F.K., Hagen, W.J., Rumlová, M., Ruml, T., Müller, B., Kräusslich, H.G. and Briggs, J.A. (2015). Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution. Nature 517(7535): 505-508

Bharat, T.A., Davey, N.E., Ulbrich, P., Riches, J.D., de Marco, A., Rumlova, M., Sachse, C., Ruml, T., Briggs, J.A. (2012). Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy. Nature 487(7407): 385-389

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