Prof. Dr. Hans-Georg Kräusslich

Department of Infectious Diseases, Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 5001
Fax:      +49 6221-56 5003
Email:   hans-georg.kraeusslich@med.uni-heidelberg.de

FIELDS OF INTEREST

Molecular virology; cell biology of virus infection; assembly, release and molecular architecture of HIV particles; HIV Protease and antiviral resistance; HIV-cell interactions; Role of lipids in HIV replication; Transmission and therapy of HIV infection.

CURRENTLY FUNDED PROJECTS

SFB638, project A9; TRR83, project 14; GRK1188; DFG project BR3635/2-1; BMBF Nanocombine; BMBF ebio Immunoquant; DZIF TTU HIV.

AWARDS & HONORS

2018 Johann Gregor Mendel medal of the Czech Academy of Sciences
2018 Gold medal of Charles University, Prague
2017 Elected Member American Academy of Microbiology
2009 Heinz Ansmann Award for AIDS research
2008 Member Heidelberg Academy of Sciences
2008 HMLS Research Award, Heidelberg
2007 Faculty medal of Heidelberg University Medical Faculty
2006 Member of the Deutsche Akademie der Naturforscher Leopoldina
. .

2004–present Director Department of Infectious Diseases, Heidelberg University
2000–present Full professor and head of virology, Heidelberg University
1996–1999 Director, Heinrich-Pette-Institute, Hamburg
1995–1999 Full professor and head of department, Heinrich-Pette-Institute, Hamburg
1993–1995 Head of junior department, German Cancer Research Centre, Heidelberg
1990 Habilitation, University of Heidelberg
1989–1993 Group leader, German Cancer Research Centre, Heidelberg
1986–1989 PostDoc, Dept. of Mol. Biology, State Univ. New York at Stony Brook
1985 MD in experimental virology (Munich)
1977–1984 Medical School (Munich)

2019-present Dean Medical Faculty Heidelberg
2019-present Chairman of the Executive Board, German Center for Infection Research (DZIF)
2015–2019 Vice-President Heidelberg Academy of Sciences
2014–2019 Vice-Dean for Research, Medical Faculty Heidelberg, Heidelberg University
2014–present Speaker SFB 1129 “Integrative analysis of pathogen replication and spread”, Heidelberg University
2007-present Member founding directorate “BioQuant”
2007–2013 Director Marsilius-Kolleg (jointly with W. Schluchter)
2006–2018 Coordinator Cluster of Excellence “Cellular Networks”
2004–present Coordinator research program “Infectious diseases”, Heidelberg University
2004–2015 Member steering committee SFB 638, University of Heidelberg
2005–2012 Coordinator DFG priority program SPP 1175 “Membrane envelopment”
2002–2011 Speaker SFB 544 “Control of tropical infectious diseases”, Heidelberg University
2002–2005 Coordinator collaborative research project “Resistance of human pathogens” (Landesstiftung Baden-Württemberg)
2001–2004 Coordinator EU (FP5) collaborative project HIV protease inhibitor resistance
1997–2000 Member steering committee SFB 545, University of Hamburg
1997–1999 Deputy speaker, DFG research group “RNA trafficking”
1994–1997 Speaker collaborative BMBF-funded AIDS-research grant, University of Heidelberg

Zila V, Margiotta E, Turoňová B, Müller TG, Zimmerli CE, Mattei S, Allegretti M, Börner K, Rada J, Müller B, Lusic M, Kräusslich HG#, Beck M# (2021). Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Cell 184: 1032-46. (#corr. author)

Müller TG, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, Laketa V, Lusic M, Müller B, Kräusslich HG (2021). HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. Elife 10:e64776.

Peukes J, Xiong X, Erlendsson S, Qu K, Wan W, Calder LJ, Schraidt O, Kummer S, Freund SMV, Kräusslich HG, Briggs JAG (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature 587:495-8.

Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA (2016). The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science. 354(6318):1434-1437

Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-8222

Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG (2014). Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. 3:e04114

Chojnacki J, Staudt T, Glass B, Bingen P, Engelhardt J, Anders M, Schneider J, Müller B, Hell SW, Kräusslich HG (2012). Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. 338:524-528

Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, *Kräusslich HG, *Martinez-Picado J. 2012. Siglec-1 Is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides. PLoS Biol. 10:e1001448

Carlson LA, Briggs JAG, B Glass B, Riches JD, Simon MN, Johnson MC, Müller, Grünewald K and Kräusslich HG (2008). Three-dimensional analysis of budding sites and released virus suggests a new model for HIV-1 morphogenesis. Cell Host Microbe. 4:592-599

Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT and Kräusslich HG(2006). The HIV lipidome: A raft with an unusual composition. 103:2641-2646

Click here for further publications.