Dr. Alessia Ruggieri

Department of Infectious Diseases, Molecular Virology Heidelberg University
69120 Heidelberg, Germany

Phone: +49 6221-56 7761
Fax:      +49 6221-56 4570
Email:   alessia.ruggieri@med.uni-heidelberg.de

FIELDS OF INTEREST

Molecular virology, dynamics of cellular stress and immune responses to RNA virus infection, quantitative live-cell Imaging

AWARDS & HONORS

2014-2016        Stipendium of Chica and Heinz Schaller Foundation

2014–present Group leader, Department of Infectious Diseases, Molecular Virology, Heidelberg University
2008–2013 Postdoc, Department of Infectious Diseases, Molecular Virology, Heidelberg University
2004–2008 Postdoc, Institute of Human Genetics, University of Saarland
1999–2003 Ph.D. Virology, Ecole Normale Supérieur de Lyon, France
1998–1999 Diploma thesis, University of Lyon, France
1995–1998 Studies in Cellular and Molecular Biology Metz and Lyon, France

2021-present Coordinator of the Integrated Research Training Group TRR319 “Young Research in RNA Modification and Processing” at Mainz/Heidelberg Universities
2017-2020 Co-coordinator of the Integrated Research Training Group TRR179 “Immunovirology” MD/PhD program at Heidelberg/Freiburg/Munich Universities
2017-present Member of steering committee TRR186, Heidelberg/Berlin Universities

(*equal corresponding author)

Haneke K, Schott J, Lindner D, Hollensen AK, Damgaard CK, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G (2020). CDK1 couples proliferation with protein synthesis. J Cell Biol. 219(3): e201906147.

Brocard M, Iadevaia V, Klein P, Hall B, Lewis G, Lu J, Burke J, Willcocks M, Parker R, Goodfellow IG, Ruggieri A, Locker N (2020). Norovirus infection results in eIF2α-independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation. PLoS Pathog. 16(1):e1008250.

Lee J-Y, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Rohr K, Qiang Y, Ritter C, Schwab Y, Schieber N, Bartenschlager M, Kallis S, Ruggieri A, Bartenschlager R (2019). Spatio-temporal coupling of the hepatitis C virus replication cycle by creation of a li-pid droplet proximal membranous replication compartment. Cell Rep. 27(12):3602-3617.e5.

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A (2017). Flavivirus infection uncouples translation suppression from cellular stress responses. mBio. 8:e02150-16

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Fu-naya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. (2017). Ultrastructural characterization of Zika virus replication facto-ries. Cell Reports. 18(9):2113–2123

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Fischl W, Scaturro P, Fischer B, Ruggieri A, Bartenschlager R (2016). Dengue virus modulates mitochondrial morphodynam-ics through the inhibition of DRP-1 for the benefit of viral replication. Cell Host Microbe. 20(3):342-56

Trotart M, Tsopoulidis N, Tibroni N, Willemsen J, Binder M, Ruggieri A, Fackler OT (2016). Sensing of HIV-1 infection in Tzm-bl cells with reconstituted expression of STING. J Virol. 90(4):2064-2076

Schmid B, Rinas M, Ruggieri A, Reuter A, Fischl W, Harder N, Bergeest J-P, Flossdorf M, Rohr K, Höfer T, Bartenschlager R (2015). Live-cell analysis and modeling identify deter-minants of attenuation of Dengue virus 2-O-methyl mutant. PLoS Pathog. 11(12):e1005345.

Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A*, Bartenschlager R* (2015). Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. J Hepatol. 63(4):829-837

Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kal-lis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R (2012). Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe. 12(1):71-85

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