Dr. Steeve Boulant
Department of Molecular Genetics & Microbiology
College of Medicine
University of Florida, Gainesville, USA
until December 2021:
Department of Infectious Diseases, Virology
University Hospital Heidelberg
69120 Heidelberg, Germany
FIELDS OF INTEREST
Virus entry, virus-host interactions, anti-viral innate immune eresponse in intestinal polarized epithelium cells, viral commensal intestinal flora, molecular mechanisms triggering viral particle entry, characterization of the dynamic uptake and intracellular trafficking of viral pathogen using live-cell confocal microscopy, quantification of virus-receptor interaction using TORF microscope and characterization of the impact of receptor clustering on virus entry, intracellular locatioan and functional aspects of innate immunity sensor proteins (TLR and RLR) in polarized cells.
AWARDS & HONORS
| 2011 | Post-doctoral fellowship (2011-2012), GlaxoSmithKline, Boston MA, USA |
| 2010 | Pilot and Feasiblity award program HDDC, Boston MA, USA |
| 2009 | Pilot and Feasiblity award program HDDC, Boston MA, USA |
| 2007 | Poster award, FASEB Liqid Droplets conference, Vermont USA |
| 2006 | Post-doctoral fellowship Marie-Curie IEF (2006-2008), Glasgow, UK |
| 2006 | Best Oral communication, UK Meeting on the Biology and Pathology of HCV |
| 2005 | Post-doctoral fellowship (2005-2006), MRC, Glasgow, UK |
| 2005 | Travel award, 11th Interantional Meeting on HCV and Related Viruses |
| 2004 | Bridging grant, FRM (2004-2005), Lyon, France |
| 2001 | EURODOC fellowsgip, Lyon-Glasgow exchange grant |
| 2012-present | Group Leader CHS Foundation, University Hospital Heidelberg |
| 2008-2012 | Post doctoral associate, Harvard Medical School Boston MA, USA |
| 2006-2008 | Marie Curie Post doctoral fellow, MRC Virology Unit Glasgow, UK |
| 2005-2006 | Post doctoral associate, MRC Virology Unit Glasgow, UK |
| 2004-2005 | Bridging grant fellow, IBCP-CNRS Lyon, France |
| 2001-2004 | PhD in Molecular Biology and Biochemistry, IBCP-CNRS, France |
| 2000-2001 | DEA in Molecular Biology and Biochemistry (Master), Lyon, France |
| 1998-2000 | Bachelor degree in Molecular Biology and Biochemistry, Lyon, France |
| 1996-1998 | Classe préparatoire Mathematic superior, Lycée Ozenne, Toulouse, France |
| 2013-2016 | Chair of the study section “Cell Biology of Viral Infections” of the Society of Virology (GfV) |
| 2010 | Co-organisor of live-cell imaging workshop, Harvard Medical School, USA |
Shah PNM, Stanifer ML, Höhn K, Engel U, Haselmann U, Bartenschlager R, Kräusslich HG, Krijnse-Locker J, Boulant S (2017). Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network. Cell Microbiol. 2017 Jul 3.
Pervolaraki K, Stanifer ML, Münchau S, Renn LA, Albrecht D, Kurzhals S, Senís E, Grimm D, Schröder-Braunstein J, Rabin RL, Boulant S (2017). Type I and type III interferons display different dependency on mitogen-activated protein kinases to mount an antiviral state in the human gut. Front Immunol. 21;8:459
Stanifer ML, Rippert A, Kazakov A, Willemsen J, Bucher D, Bender S, Bartenschlager R, Binder M, Boulant S (2016). Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling. Cell Microbiol. 18(12):1831-1845
Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC (2014). Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 8:717–726
Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Whelan S, Nibert ML, Kirchhausen T (2013). Similar uptake but different trafficking and escape routes of reovirus virions and ISVPs imaged in polarized MDCK cells. Mol Biol Cell. 24:1196-1207
Cocucci E, Aguet F, Boulant S, Kirchhausen T (2012). The first 10 seconds in the life of a clathrin coated pit. Cell. 150:495-507
Boulant S*, Ivanovic T*, Ehrlich M, Arnold MM, Kirchhausen T, Nibert ML (2011). Recruitment of cellular clathrin to viral factories by mammalian orthoreovirus protein μNS. Traffic 9:1179-1195
Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T (2011). Actin provides additional force to counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 13:1124-1131
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC (2010). Peroxisomes and mitochondria cooperate to induce antiviral innate immunity. Cell 141:668-681
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