Brügger, Britta

Prof. Dr. Britta Brügger

Heidelberg University Biochemistry Center (BZH)
69120 Heidelberg, Germany

Phone: +49 6221-54 5326
Fax:      +49 6221-54 4366


Protein-lipid interactions, roles of lipids in fusion and fission of viral particles, regulation of membrane receptor activity by lipids, lipids as cofactors for protein function, intracellular lipid sorting, lipidomics, electrospray-ionisation high resolution mass spectrometry.


2015 Walter A. Shaw Young Investigator Award in Lipid Research
2000 – 2002 Peter and Traudl Engelhorn fellowship
1998 – 2000 EMBO long term fellowship
1998 PhD with summa cum laude
since 2014 W3 professor at the Heidelberg University Biochemistry Center
2007 Habilitation, University of Heidelberg
2006-present Head of CellNetworks Lipidomis platform, Heidelberg
2002-present Senior Scientist, Heidelberg University Biochemistry Center
2000-2002 Postdoctoral research fellow at the Heidelberg University Biochemistry Center, Heidelberg
1998-2000 Postdoctoral research fellow at the Memorial Sloan Kettering Cancer Center, New York, USA
1994-1998 PhD thesis with Prof. Dr. Felix Wieland at Institute for Biochemistry, Ruprecht Karls University, Heidelberg
1993-1994 Diploma thesis at Göttingen University
1990-1993 Studies in Biochemistry at Frankfurt University
1988-1990  Studies in Biology at Frankfurt University
2016-present Member of the DFG panel 201-01 ‘Biochemistry/Biophysics’
2014-present Coordinator of the Biochemistry Bachelor and Master courses
2014-present Equality representative and member of steering committee of SFB 1129 “Integrative analysis of pathogen replication and spread”
2014-present Dean of Studies Biochemistry, Heidelberg University
2012-present Member of the Leibniz-Institut für Analytische Wissenschaften – ISAS Consulting Committee
2010-present Vice-coordinator SFB/TRR 83

Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT (2017). The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 2017 Aug 18;292(33):13702-13713. doi: 10.107 4/jbc.M117.797332.

Gerl M. J, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Ozbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B (2016). Sphingosine-1-phosphate lyase deficient cells as a tool to study Protein lipid interactionsPloS one. 11:e0153009

Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y (2016). Morphology and molecular composition of purified bovine viral diarrhea virus envelopePLoS Pathog. 12(3):e1005476

Hacke M, Bjorkholm P, Hellwig A, Himmels P, de Almodovar CR, Brügger B, Wieland F, Ernst AM (2015). Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane and cholesterol. Nat Commun. 6,7688, PMID 26158910

Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, Brügger B (2014). Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometryAnal Chem. 86(8):3722-3726

Björkholm P, Ernst AM, Hacke M, Wieland F, Brügger B, von Heijne G (2014). Identification of novel sphingolipid-binding motifs in mammalian membrane proteinsBiochimica et biophysica acta 1838, 2066-2070. *co-corresponding author

Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, Brügger B (2012). Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain. Nature 2012 Jan 9;481(7382): 525-9

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M (2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008 Feb 29;319(5867):1244-7

Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B (2008). Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 2008 Jan;49(1):251-62

Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG (2006). The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A. 2006 Feb 21;103 (8):2641-6

Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT (2000). Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 2000 Oct 30;151(3):507-18

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