Prof. Dr. Britta Brügger
Heidelberg University Biochemistry Center (BZH)
69120 Heidelberg, Germany
Phone: +49 6221-54 5326
Fax: +49 6221-54 4366
E-Mail
FIELDS OF INTEREST
Protein-lipid interactions, roles of lipids in fusion and fission of viral particles, regulation of membrane receptor activity by lipids, lipids as cofactors for protein function, intracellular lipid sorting, lipidomics, electrospray-ionisation high resolution mass spectrometry.
AWARDS & HONORS
| 2015 | Walter A. Shaw Young Investigator Award in Lipid Research |
| 2000 – 2002 | Peter and Traudl Engelhorn fellowship |
| 1998 – 2000 | EMBO long term fellowship |
| 1998 | PhD with summa cum laude |
| since 2014 | W3 professor at the Heidelberg University Biochemistry Center |
| 2007 | Habilitation, University of Heidelberg |
| 2006-present | Head of CellNetworks Lipidomis platform, Heidelberg |
| 2002-present | Senior Scientist, Heidelberg University Biochemistry Center |
| 2000-2002 | Postdoctoral research fellow at the Heidelberg University Biochemistry Center, Heidelberg |
| 1998-2000 | Postdoctoral research fellow at the Memorial Sloan Kettering Cancer Center, New York, USA |
| 1994-1998 | PhD thesis with Prof. Dr. Felix Wieland at Institute for Biochemistry, Ruprecht Karls University, Heidelberg |
| 1993-1994 | Diploma thesis at Göttingen University |
| 1990-1993 | Studies in Biochemistry at Frankfurt University |
| 1988-1990 | Studies in Biology at Frankfurt University |
| 2016-present | Member of the DFG panel 201-01 ‘Biochemistry/Biophysics’ |
| 2014-present | Coordinator of the Biochemistry Bachelor and Master courses |
| 2014-present | Equality representative and member of steering committee of SFB 1129 “Integrative analysis of pathogen replication and spread” |
| 2014-present | Dean of Studies Biochemistry, Heidelberg University |
| 2012-present | Member of the Leibniz-Institut für Analytische Wissenschaften – ISAS Consulting Committee |
| 2010-present | Vice-coordinator SFB/TRR 83 |
Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT (2017). The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 2017 Aug 18;292(33):13702-13713. doi: 10.107 4/jbc.M117.797332.
Gerl M. J, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Ozbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B (2016). Sphingosine-1-phosphate lyase deficient cells as a tool to study Protein lipid interactions. PloS one. 11:e0153009
Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y (2016). Morphology and molecular composition of purified bovine viral diarrhea virus envelope. PLoS Pathog. 12(3):e1005476
Hacke M, Bjorkholm P, Hellwig A, Himmels P, de Almodovar CR, Brügger B, Wieland F, Ernst AM (2015). Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane and cholesterol. Nat Commun. 6,7688, PMID 26158910
Gerl MJ, Sachsenheimer T, Grzybek M, Coskun U, Wieland FT, Brügger B (2014). Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal Chem. 86(8):3722-3726
Björkholm P, Ernst AM, Hacke M, Wieland F, Brügger B, von Heijne G (2014). Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochimica et biophysica acta 1838, 2066-2070. *co-corresponding author
Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, Brügger B (2012). Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain. Nature 2012 Jan 9;481(7382): 525-9
Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M (2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008 Feb 29;319(5867):1244-7
Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B (2008). Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 2008 Jan;49(1):251-62
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG (2006). The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A. 2006 Feb 21;103 (8):2641-6
Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT (2000). Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 2000 Oct 30;151(3):507-18
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